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It was proposed to monitor in free moving rats, by in vivo voltammetry, the effects of intracerebroventricular (i.c.v.) administration of drugs known to act on the synthesis of dopamine (DA), using an original multifiber carbon electrode which enables without-discontinuity long-term recordings in extracellular DA release. Results show that i.c.v. administration of alpha-methyl-p-tyrosine, gamma-butyrolactone, and apomorphine induced long-term depression in striatal DA release, over periods of time of more than 24 h. These results are in agreement with the dopaminergic hypothesis; and we conclude that i.c.v. administration of drugs and the use of the multifiber carbon electrode constitutes a valuable tool to monitor DA metabolism in chronically implanted animals.
J H Abraini, and
L Raharison, and
J C Rostain
September 1986,
Brain research,
J H Abraini, and
L Raharison, and
J C Rostain
January 1986,
Neuroscience letters,
J H Abraini, and
L Raharison, and
J C Rostain
February 1994,
Neuroreport,
J H Abraini, and
L Raharison, and
J C Rostain
April 1994,
Brain research,
J H Abraini, and
L Raharison, and
J C Rostain
July 1993,
Neuroscience letters,
J H Abraini, and
L Raharison, and
J C Rostain
June 1989,
Stroke,
J H Abraini, and
L Raharison, and
J C Rostain
November 1991,
Pharmacology, biochemistry, and behavior,
J H Abraini, and
L Raharison, and
J C Rostain
February 1988,
The American journal of physiology,
J H Abraini, and
L Raharison, and
J C Rostain
May 1986,
Neuroscience letters,
J H Abraini, and
L Raharison, and
J C Rostain
September 1984,
Neuroscience letters,
