BIOMAT Database Logo BIOMAT Database Logo

Somatostatin augments long-term potentiation of the mossy fiber-CA3 system in guinea-pig hippocampal slices. 1991

N Matsuoka, and S Kaneko, and M Satoh
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.

The effect of exogenously applied somatostatin (1-14), which is one of the candidates of neuromodulators in the hippocampus, on long-term potentiation (LTP) was investigated in the CA1 and CA3 subfields of guinea-pig hippocampal slices. In the mossy fiber-CA3 pyramidal cell system, the magnitude of LTP of both population excitatory postsynaptic potential (pEPSP) and population spike was significantly augmented by somatostatin (10(-7)-10(-6) M) perfused before and during tetanic stimulation which never affected basal amplitude of population spikes before tetanus. The enhancement of LTP by somatostatin lasted for at least one hour after washout. On the other hand, somatostatin at the most effective concentration (3.2 x 10(-7) M) in the above described system failed to affect the magnitude of the LTP of population spikes in Schaffer collateral-CA1 pathway. The enhancing effect of somatostatin on LTP in the mossy fiber CA3 system was inhibited either by a muscarinic antagonist, scopolamine (10(-6) M), or a beta-adrenoceptor antagonist, timolol (10(-6) M). These results suggest that somatostatin enhances the production of LTP in the mossy fiber-CA3 pathway of the guinea-pig hippocampus through the intervention of cholinergic and noradrenergic neurons.

UI MeSH Term Description Entries
D008297 Male Males
D009412 Nerve Fibers Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM. Cerebellar Mossy Fibers,Mossy Fibers, Cerebellar,Cerebellar Mossy Fiber,Mossy Fiber, Cerebellar,Nerve Fiber
D011712 Pyramidal Tracts Fibers that arise from cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord. Many authorities say the pyramidal tracts include both the corticospinal and corticobulbar tracts. Corticobulbar Tracts,Corticospinal Tracts,Decussation, Pyramidal,Corticobulbar Tract,Corticospinal Tract,Pyramidal Decussation,Pyramidal Tract,Tract, Corticobulbar,Tract, Corticospinal,Tract, Pyramidal,Tracts, Corticobulbar,Tracts, Corticospinal,Tracts, Pyramidal
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D005071 Evoked Potentials Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported. Event Related Potential,Event-Related Potentials,Evoked Potential,N100 Evoked Potential,P50 Evoked Potential,N1 Wave,N100 Evoked Potentials,N2 Wave,N200 Evoked Potentials,N3 Wave,N300 Evoked Potentials,N4 Wave,N400 Evoked Potentials,P2 Wave,P200 Evoked Potentials,P50 Evoked Potentials,P50 Wave,P600 Evoked Potentials,Potentials, Event-Related,Event Related Potentials,Event-Related Potential,Evoked Potential, N100,Evoked Potential, N200,Evoked Potential, N300,Evoked Potential, N400,Evoked Potential, P200,Evoked Potential, P50,Evoked Potential, P600,Evoked Potentials, N100,Evoked Potentials, N200,Evoked Potentials, N300,Evoked Potentials, N400,Evoked Potentials, P200,Evoked Potentials, P50,Evoked Potentials, P600,N1 Waves,N2 Waves,N200 Evoked Potential,N3 Waves,N300 Evoked Potential,N4 Waves,N400 Evoked Potential,P2 Waves,P200 Evoked Potential,P50 Waves,P600 Evoked Potential,Potential, Event Related,Potential, Event-Related,Potential, Evoked,Potentials, Event Related,Potentials, Evoked,Potentials, N400 Evoked,Related Potential, Event,Related Potentials, Event,Wave, N1,Wave, N2,Wave, N3,Wave, N4,Wave, P2,Wave, P50,Waves, N1,Waves, N2,Waves, N3,Waves, N4,Waves, P2,Waves, P50
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012601 Scopolamine An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Its many uses include an anesthetic premedication, the treatment of URINARY INCONTINENCE and MOTION SICKNESS, an antispasmodic, and a mydriatic and cycloplegic. Hyoscine,Scopolamine Hydrobromide,Boro-Scopol,Isopto Hyoscine,Kwells,Scoburen,Scopace,Scopoderm TTS,Scopolamine Cooper,Transderm Scop,Transderm-V,Travacalm HO,Vorigeno,Boro Scopol,Transderm V
D013004 Somatostatin A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal. Cyclic Somatostatin,Somatostatin-14,Somatotropin Release-Inhibiting Hormone,SRIH-14,Somatofalk,Somatostatin, Cyclic,Somatotropin Release-Inhibiting Factor,Stilamin,Somatostatin 14,Somatotropin Release Inhibiting Factor,Somatotropin Release Inhibiting Hormone

Related Publications

N Matsuoka, and S Kaneko, and M Satoh
Indeloxazine augments long-term potentiation in the mossy fiber-CA3 system of guinea pig hippocampal slices.
December 1989, Journal of pharmacobio-dynamics,
N Matsuoka, and S Kaneko, and M Satoh
Effect of vinconate on long-term potentiation in a mossy fiber-CA3 system of guinea pig hippocampal slices.
July 1994, Biological & pharmaceutical bulletin,
N Matsuoka, and S Kaneko, and M Satoh
YM-14673, a new thyrotropin-releasing hormone analog, augments long-term potentiation in the mossy fiber-CA3 system of guinea pig hippocampal slices.
February 1992, Journal of pharmacobio-dynamics,
N Matsuoka, and S Kaneko, and M Satoh
FK960, a novel potential anti-dementia drug, augments long-term potentiation in mossy fiber-CA3 pathway of guinea-pig hippocampal slices.
June 1998, Brain research,
N Matsuoka, and S Kaneko, and M Satoh
CCKB-receptor activation augments the long-term potentiation in guinea pig hippocampal slices.
August 1995, Japanese journal of pharmacology,
N Matsuoka, and S Kaneko, and M Satoh
Aniracetam augments, and midazolam inhibits, the long-term potentiation in guinea-pig hippocampal slices.
July 1986, Neuroscience letters,
N Matsuoka, and S Kaneko, and M Satoh
Effects of thyrotropin-releasing hormone and a related analog, CNK-602A, on long-term potentiation in the mossy fiber-CA3 pathway of guinea pig hippocampal slices.
July 1991, Brain research,
N Matsuoka, and S Kaneko, and M Satoh
Frequency-dependent associative long-term potentiation at the hippocampal mossy fiber-CA3 synapse.
October 1994, Proceedings of the National Academy of Sciences of the United States of America,
N Matsuoka, and S Kaneko, and M Satoh
Benzodiazepine inverse agonists augment long-term potentiation in CA1 and CA3 of guinea pig hippocampal slices.
February 1993, Neuropharmacology,
N Matsuoka, and S Kaneko, and M Satoh
Bidirectional modulation of long-term potentiation by carbachol via M1 and M2 muscarinic receptors in guinea pig hippocampal mossy fiber-CA3 synapses.
August 1993, Brain research,
Copied contents to your clipboard!