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The effects of aniracetam, a nootropic drug, and midazolam, which produces amnesia, on the long-term potentiation (LTP) of population spikes was investigated using hippocampal slices (CA3 area) from the guinea pig. Aniracetam at concentrations of 10(-7) and 10(-8) M, but not at 10(-6) M, significantly augmented LTP. On the other hand, midazolam (10(-9) M) significantly suppressed LTP. The suppressive effect was antagonized by Ro 15-1788 (10(-8) M). Both drugs did not affect the population spikes in the absence of tetanic stimulation at those concentrations. It was suggested that in vitro application of LTP is a feasible model system for evaluating the nootropic activity of drugs.
M Satoh, and
K Ishihara, and
T Iwama, and
H Takagi
August 1995,
Japanese journal of pharmacology,
M Satoh, and
K Ishihara, and
T Iwama, and
H Takagi
July 1991,
Brain research,
M Satoh, and
K Ishihara, and
T Iwama, and
H Takagi
July 1996,
Neuroscience letters,
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K Ishihara, and
T Iwama, and
H Takagi
August 1994,
Neuroscience letters,
M Satoh, and
K Ishihara, and
T Iwama, and
H Takagi
January 1991,
The European journal of neuroscience,
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K Ishihara, and
T Iwama, and
H Takagi
January 1991,
Neuroscience,
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K Ishihara, and
T Iwama, and
H Takagi
September 2000,
Epilepsia,
M Satoh, and
K Ishihara, and
T Iwama, and
H Takagi
July 1998,
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology,
M Satoh, and
K Ishihara, and
T Iwama, and
H Takagi
June 1998,
Brain research,
M Satoh, and
K Ishihara, and
T Iwama, and
H Takagi
February 1997,
Brain research,
