The human genes for complement components 6 (C6) and 9 (C9) are closely linked on chromosome 5. 1991

S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
Department of Animal Science, Agricultural University, Norway.

We have used a cDNA probe for human complement component 9 (C9), which detects three DNA polymorphisms, to analyse the inheritance of C9 in families informative for C6 protein variants. We found that these genes are closely linked with a lod score of 9.28 at recombination fraction 0.00. There is not indication of allelic association.

UI MeSH Term Description Entries
D008126 Lod Score The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds." Lod Scores,Score, Lod,Scores, Lod
D010375 Pedigree The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition. Family Tree,Genealogical Tree,Genealogic Tree,Genetic Identity,Identity, Genetic,Family Trees,Genealogic Trees,Genealogical Trees,Genetic Identities,Identities, Genetic,Tree, Family,Tree, Genealogic,Tree, Genealogical,Trees, Family,Trees, Genealogic,Trees, Genealogical
D011995 Recombination, Genetic Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses. Genetic Recombination,Recombination,Genetic Recombinations,Recombinations,Recombinations, Genetic
D012150 Polymorphism, Restriction Fragment Length Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment. RFLP,Restriction Fragment Length Polymorphism,RFLPs,Restriction Fragment Length Polymorphisms
D002896 Chromosomes, Human, Pair 6 A specific pair GROUP C CHROMSOMES of the human chromosome classification. Chromosome 6
D003183 Complement C6 A 105-kDa serum glycoprotein with significant homology to the other late complement components, C7-C9. It is a polypeptide chain cross-linked by 32 disulfide bonds. C6 is the next complement component to bind to the membrane-bound COMPLEMENT C5B in the assembly of MEMBRANE ATTACK COMPLEX. It is encoded by gene C6. C6 Complement,Complement 6,Complement Component 6,C6, Complement,Complement, C6,Component 6, Complement
D003186 Complement C9 A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections. C9 Complement,Complement 9,Complement Component 9,C9, Complement,Complement, C9,Component 9, Complement
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015252 Deoxyribonucleases, Type II Site-Specific Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4. DNA Restriction Enzymes, Type II,DNase, Site-Specific, Type II,Restriction Endonucleases, Type II,Type II Restriction Enzymes,DNase, Site Specific, Type II,Deoxyribonucleases, Type II, Site Specific,Deoxyribonucleases, Type II, Site-Specific,Site-Specific DNase, Type II,Type II Site Specific DNase,Type II Site Specific Deoxyribonucleases,Type II Site-Specific DNase,Type II Site-Specific Deoxyribonucleases,Deoxyribonucleases, Type II Site Specific,Site Specific DNase, Type II

Related Publications

S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
May 1990, Annals of human genetics,
S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
April 1988, Blood,
S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
November 1989, Endocrinology,
S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
January 1993, Immunogenetics,
S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
January 1991, Immunogenetics,
S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
February 1991, Genetical research,
S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
January 1992, Mammalian genome : official journal of the International Mammalian Genome Society,
S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
March 1977, The New England journal of medicine,
S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
January 1995, Genomics,
S Rogne, and O Myklebost, and J H Olving, and H T Kyrkjebø, and R Jonassen, and B Olaisen, and T Gedde-Dahl
February 1994, The Journal of biological chemistry,
Copied contents to your clipboard!