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Samples of synovial fluids aspirated from patients with septic arthritis prior to the commencement of any treatment contained active metalloproteinases but no proteinase inhibitory activity. We therefore assayed these samples for proteinase-inhibitor complexes. Although no biologically active alpha 2-macroglobulin or tissue inhibitor of metalloproteinase (TIMP) was present in the fluids, immunoassay of the samples clearly showed that high molecular weight proteinase-TIMP complexes were present. It is proposed that high levels of active metalloproteinases are released from neutrophils into septic synovial fluids and that these proteinases complex all the available TIMP, forming metalloproteinase-TIMP complexes.
T Cawston, and
P McLaughlan, and
R Coughlan, and
V Kyle, and
B Hazleman
October 1989,
British journal of rheumatology,
T Cawston, and
P McLaughlan, and
R Coughlan, and
V Kyle, and
B Hazleman
March 1993,
Annals of the rheumatic diseases,
T Cawston, and
P McLaughlan, and
R Coughlan, and
V Kyle, and
B Hazleman
March 1993,
Arthritis and rheumatism,
T Cawston, and
P McLaughlan, and
R Coughlan, and
V Kyle, and
B Hazleman
October 1989,
The Journal of biological chemistry,
T Cawston, and
P McLaughlan, and
R Coughlan, and
V Kyle, and
B Hazleman
March 1989,
Development (Cambridge, England),
T Cawston, and
P McLaughlan, and
R Coughlan, and
V Kyle, and
B Hazleman
October 2001,
Nihon rinsho. Japanese journal of clinical medicine,
T Cawston, and
P McLaughlan, and
R Coughlan, and
V Kyle, and
B Hazleman
November 2009,
Journal of neurotrauma,
T Cawston, and
P McLaughlan, and
R Coughlan, and
V Kyle, and
B Hazleman
August 1992,
Biochemical Society transactions,
T Cawston, and
P McLaughlan, and
R Coughlan, and
V Kyle, and
B Hazleman
August 1989,
The Biochemical journal,
T Cawston, and
P McLaughlan, and
R Coughlan, and
V Kyle, and
B Hazleman
January 1992,
Matrix (Stuttgart, Germany). Supplement,
