BIOMAT Database Logo BIOMAT Database Logo

Biological evaluation of chalcones and analogues as hypolipidemic agents. 2006

Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Departament of Biochemistry, Universidade Federal de Santa Catarina (UFSC), Florianopolis, Brazil.

In order to evaluate the anti-hyperlipidemic effect of synthetic chalcones and some analogues, nineteen compounds with different substituents in both rings were synthesized and hypolipidemic activities were measured in vivo using Triton WR1339 acute and hypercaloric chronic assays. 4',4-dichlorochalcone, 3',4',4-trichlorochalcone, and 4'-chlorochalcone gave an excellent decrease in serum total cholesterol and triglycerides in the acute assay. These compounds also showed significant anti-lipidemic activity in the chronic assay.

UI MeSH Term Description Entries
D006949 Hyperlipidemias Conditions with excess LIPIDS in the blood. Hyperlipemia,Hyperlipidemia,Lipemia,Lipidemia,Hyperlipemias,Lipemias,Lipidemias
D008078 Cholesterol, LDL Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol. LDL Cholesterol,Cholesteryl Linoleate, LDL,LDL Cholesteryl Linoleate,Low Density Lipoprotein Cholesterol,beta-Lipoprotein Cholesterol,Cholesterol, beta-Lipoprotein,beta Lipoprotein Cholesterol
D008297 Male Males
D004041 Dietary Fats Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados. Fats, Dietary,Dietary Fat,Fat, Dietary
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000960 Hypolipidemic Agents Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. Antihyperlipidemic,Antilipemic,Antilipemic Agents,Antilipemic Drug,Hypolipidemic Agent,Hypolipidemic Drug,Antihyperlipemics,Antihyperlipidemics,Antilipemic Drugs,Antilipemics,Hypolipidemic Drugs,Agent, Hypolipidemic,Agents, Antilipemic,Agents, Hypolipidemic,Drug, Antilipemic,Drug, Hypolipidemic,Drugs, Antilipemic,Drugs, Hypolipidemic
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D014280 Triglycerides An ester formed from GLYCEROL and three fatty acid groups. Triacylglycerol,Triacylglycerols,Triglyceride
D015243 Cholesterol, VLDL Cholesterol which is contained in or bound to very low density lipoproteins (VLDL). High circulating levels of VLDL cholesterol are found in HYPERLIPOPROTEINEMIA TYPE IIB. The cholesterol on the VLDL is eventually delivered by LOW-DENSITY LIPOPROTEINS to the tissues after the catabolism of VLDL to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LDL. VLDL Cholesterol,Pre-beta-Lipoprotein Cholesterol,Prebetalipoprotein Cholesterol,Very Low Density Lipoprotein Cholesterol,Cholesterol, Pre-beta-Lipoprotein,Cholesterol, Prebetalipoprotein,Pre beta Lipoprotein Cholesterol

Related Publications

Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Synthesis and biological evaluation of indolyl chalcones as antitumor agents.
July 2010, Bioorganic & medicinal chemistry letters,
Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Synthesis and biological evaluation of chalcones as potential antileishmanial agents.
June 2014, European journal of medicinal chemistry,
Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Design, synthesis, and biological evaluation of prenylated chalcones as vasorelaxant agents.
July 2009, Archiv der Pharmazie,
Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Syntheses and biological evaluation of alkanediamines as antioxidant and hypolipidemic agents.
December 2001, Bioorganic & medicinal chemistry,
Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation.
May 2011, Bioorganic & medicinal chemistry,
Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
May 2008, Bioorganic & medicinal chemistry,
Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Design, synthesis, docking and biological evaluation of chalcones as promising antidiabetic agents.
January 2020, Bioorganic chemistry,
Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Synthesis and biological evaluation of acetylenic chalcones as novel anti-inflammatory agents.
January 2015, Medicinal chemistry (Shariqah (United Arab Emirates)),
Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Design, synthesis and biological evaluation of several aromatic substituted chalcones as antimalarial agents.
December 2020, Drug development research,
Lorena Santos, and Rozangela Curi Pedrosa, and Rogério Correa, and Valdir Cechinel Filho, and Ricardo José Nunes, and Rosendo Augusto Yunes
Synthesis and biological evaluation of orally active hypolipidemic agents.
August 2011, Journal of medicinal chemistry,
Copied contents to your clipboard!