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Telomere shortening in human HL60 cells by treatment with deoxyguanosine analogs. 2004
Toyofumi Yamaguchi, and
Hazuki Takahashi, and
Yoko Harada, and
Masato Yoshikawa, and
Saori Iyono, and
Motoko Inomata, and
Tokumi Maruyama, and
Mineo Saneyoshi
Department of Biological Sciences, Teikyo University of Science and Technology, Uenohara, Yamanashi 409-0193, Japan.
Telomerase is a cellular endogenous reverse transcriptase thought to play an important role in the maintenance of telomere length. We investigated the effects of 3'-azido-2',3'-dideoxyguanosine (AZddG) and carbocyclic oxetanocin G (C.OXT-G), of which the triphosphate derivatives AZddGTP and C.OXT-GTP show potent telomerase inhibition, on telomere length of human HL60 cells in culture. Although AZddG caused more significant telomere shortening than C.OXT-G, only a slight decrease of cell growth rate was observed.
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