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Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents. 2007
Byoung-Kwon Chun, and
Peiyuan Wang, and
Abdalla Hassan, and
Jinfa Du, and
Phillip M Tharnish, and
Eisuke Murakami, and
Lieven Stuyver, and
Michael J Otto, and
Raymond F Schinazi, and
Kyoichi A Watanabe
Pharmasset, Inc., Princeton, New Jersey 08540, USA. kwon.chun@pharmasset.com
In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.
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