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Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents. 2011
Hong-wang Zhang, and
Longhu Zhou, and
Steven J Coats, and
Tamara R McBrayer, and
Phillip M Tharnish, and
Lavanya Bondada, and
Mervi Detorio, and
Sarah A Amichai, and
Melissa D Johns, and
Tony Whitaker, and
Raymond F Schinazi
Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.
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