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The half-life of plasma cortisol in the rhesus monkey (M. mulatta), determined by two methods, was about 130 min and longer than that in man; it was unaffected by administration of dexamethasone. Dexamethasone (5 mg, i.v.) immediately inhibited the secretion of ACTH from the monkey pituitary. The plasma half-life of NH2-terminal immunoreactive ACTH was found to be about 55 min which was much longer than the biological half-life. The adrenal synthesis of cortisol was inhibited by metyrapone which caused a prompt increase in the plasma concentration of ACTH and 11-deoxycortisol. The hypothalamic-pituitary-adrenal system of the rhesus monkey sedated with phencyclidine hydrochloride responded rapidly to alteration in the level of steroids in the circulation.
K D Setchell, and
L H Rees, and
R L Himsworth
November 1975,
The Journal of endocrinology,
K D Setchell, and
L H Rees, and
R L Himsworth
December 1976,
The Journal of endocrinology,
K D Setchell, and
L H Rees, and
R L Himsworth
October 1969,
Journal of the American Veterinary Medical Association,
K D Setchell, and
L H Rees, and
R L Himsworth
October 1978,
American journal of obstetrics and gynecology,
K D Setchell, and
L H Rees, and
R L Himsworth
November 1980,
Biology of reproduction,
K D Setchell, and
L H Rees, and
R L Himsworth
March 1946,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K D Setchell, and
L H Rees, and
R L Himsworth
September 1969,
Obstetrics and gynecology,
K D Setchell, and
L H Rees, and
R L Himsworth
November 1971,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K D Setchell, and
L H Rees, and
R L Himsworth
March 1980,
The Journal of endocrinology,
K D Setchell, and
L H Rees, and
R L Himsworth
April 1982,
The Journal of endocrinology,
