Ectopic expression of a recessive resistance gene generates dominant potyvirus resistance in plants. 2007

Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
Department of Plant Breeding and Genetics, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA.

Despite long-standing plant breeding investments and early successes in genetic engineering, plant viral pathogens still cause major losses in agriculture worldwide.Early transgenic approaches involved the expression of pathogen-derived sequences that provided limited protection against relatively narrow ranges of viral pathotypes. In contrast,this study demonstrates that the ectopic expression of pvr1, a recessive gene from Capsicum chinense, results in dominant broad-spectrum potyvirus resistance in transgenic tomato plants (Solanum lycopersicum). The pvr1 locus in pepper encodes the eukaryotic translation initiation factor eIF4E. Naturally occurring point mutations at this locus result in monogenic recessive broad-spectrum potyvirus resistance that has been globally deployed via plant breeding programmes for more than 50 years. Transgenic tomato progenies that over-expressed the Capsicum pvr1 allele showed dominant resistance to several tobacco etch virus strains and other potyviruses, including pepper mottle virus, a range of protection similar to that observed in pepper homozygous for the pvr1 allele.

UI MeSH Term Description Entries
D010935 Plant Diseases Diseases of plants. Disease, Plant,Diseases, Plant,Plant Disease
D002212 Capsicum A plant genus of the family SOLANACEAE. The hot peppers yield CAPSAICIN, which activates VANILLOID RECEPTORS. Several varieties have sweet or pungent edible fruits that are used as vegetables when fresh and spices when the pods are dried. Bell Pepper,Cayenne Pepper,Chili Pepper,Chilli Pepper,Green Pepper,Jalapeno Pepper,Paprika,Pimiento,Red Pepper,Capsicum annuum,Cayenne,Chile Pepper,Hot Pepper,Sweet Pepper,Bell Peppers,Cayenne Peppers,Chile Peppers,Chili Peppers,Chilli Peppers,Green Peppers,Hot Peppers,Jalapeno Peppers,Pepper, Bell,Pepper, Cayenne,Pepper, Chile,Pepper, Chili,Pepper, Chilli,Pepper, Green,Pepper, Hot,Pepper, Jalapeno,Pepper, Red,Pepper, Sweet,Peppers, Bell,Peppers, Cayenne,Peppers, Chile,Peppers, Chili,Peppers, Chilli,Peppers, Green,Peppers, Hot,Peppers, Jalapeno,Peppers, Red,Peppers, Sweet,Red Peppers,Sweet Peppers
D005808 Genes, Recessive Genes that influence the PHENOTYPE only in the homozygous state. Conditions, Recessive Genetic,Genetic Conditions, Recessive,Recessive Genetic Conditions,Condition, Recessive Genetic,Gene, Recessive,Genetic Condition, Recessive,Recessive Gene,Recessive Genes,Recessive Genetic Condition
D014777 Virus Diseases A general term for diseases caused by viruses. Viral Diseases,Viral Infections,Virus Infections,Disease, Viral,Disease, Virus,Diseases, Viral,Diseases, Virus,Infection, Viral,Infection, Virus,Infections, Viral,Infections, Virus,Viral Disease,Viral Infection,Virus Disease,Virus Infection
D060467 Disease Resistance The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants. Resistance, Disease,Disease Resistances,Resistances, Disease
D017800 Potyvirus A large genus of plant viruses of the family POTYVIRIDAE which infect mainly plants of the Solanaceae. Transmission is primarily by aphids in a non-persistent manner. The type species is potato virus Y. Potato Virus Y,Potato Virus Ys,Potyviruses,Virus Ys, Potato,Ys, Potato Virus
D030821 Plants, Genetically Modified PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING. Genetically Modified Plants,Plants, Transgenic,Transgenic Plants,GMO Plants,Genetically Engineered Plants,Engineered Plant, Genetically,Engineered Plants, Genetically,GMO Plant,Genetically Engineered Plant,Genetically Modified Plant,Modified Plant, Genetically,Modified Plants, Genetically,Plant, GMO,Plant, Genetically Engineered,Plant, Genetically Modified,Plant, Transgenic,Plants, GMO,Plants, Genetically Engineered,Transgenic Plant
D032322 Solanum A plant genus of the family SOLANACEAE. Members contain SOLANACEOUS ALKALOIDS. Some species in this genus are called deadly nightshade which is also a common name for ATROPA BELLADONNA. Horsenettle,Nettle, Horse,Nightshade,Nightshade, Bitter,Nightshade, Laciniate,Poroporo,Trompillo,Solanum dulcamara,Solanum laciniatum,Bitter Nightshade,Bitter Nightshades,Horse Nettle,Horse Nettles,Horsenettles,Laciniate Nightshade,Laciniate Nightshades,Nettles, Horse,Nightshades,Nightshades, Bitter,Nightshades, Laciniate,Poroporos,Solanum dulcamaras,Solanum laciniatums,Solanums,Trompillos,dulcamara, Solanum,laciniatum, Solanum
D039561 Eukaryotic Initiation Factor-4E A peptide initiation factor that binds specifically to the 5' MRNA CAP STRUCTURE of MRNA in the CYTOPLASM. It is a component of the trimeric complex EIF4F. EIF-4E,Peptide Initiation Factor EIF-4E,CDC33 Gene Product,EIF4E,Eukaryotic Peptide Initiation Factor-4E,EIF 4E,Eukaryotic Initiation Factor 4E,Eukaryotic Peptide Initiation Factor 4E,Factor-4E, Eukaryotic Initiation,Initiation Factor-4E, Eukaryotic,Peptide Initiation Factor EIF 4E

Related Publications

Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
November 2005, Molecular genetics and genomics : MGG,
Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
January 2018, Phytopathology,
Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
January 1995, Molecular plant-microbe interactions : MPMI,
Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
November 1998, The Journal of general virology,
Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
July 2001, Journal of virology,
Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
May 2023, Plant biotechnology journal,
Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
November 2004, The Plant journal : for cell and molecular biology,
Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
December 1986, TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik,
Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
February 2004, Transgenic research,
Byoung-Cheorl Kang, and Inhwa Yeam, and Hanxia Li, and Kari W Perez, and Molly M Jahn
October 2016, Molecular plant pathology,
Copied contents to your clipboard!