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Stereological electron microscopic analysis of the rat hypothalamic ventromedial nucleus (VMN) throughout postnatal development revealed that synaptogenesis takes place up to day 45. Our results disclosed a sexual dimorphism in the synaptic organization of the neuropil of the ventrolateral (VL) subdivision of the VMN. The numerical densities of spine and shaft synapses in the adult male were higher than in the female. A dimorphic pattern in the numerical density of spine synapses occurred as early as day 5, and was present throughout postnatal life, even though in the adult rats both spine and shaft synapses were sexually dimorphic. Neonatal treatment of female rats with testosterone increased the numerical density of axodendritic synapses, inducing a pattern similar to the adult male. On the other hand, administration of tamoxifen to newborn male rats significantly reduced the numerical density of spine synapses to levels comparable to normal female rats.
L D Pozzo Miller, and
A Aoki
February 1992,
Sheng li xue bao : [Acta physiologica Sinica],
L D Pozzo Miller, and
A Aoki
June 2011,
Journal of neuroendocrinology,
L D Pozzo Miller, and
A Aoki
March 1980,
Experimental neurology,
L D Pozzo Miller, and
A Aoki
May 1996,
Behavioural brain research,
L D Pozzo Miller, and
A Aoki
January 1983,
Folia morphologica,
L D Pozzo Miller, and
A Aoki
May 1973,
Brain research,
L D Pozzo Miller, and
A Aoki
March 2003,
The European journal of neuroscience,
L D Pozzo Miller, and
A Aoki
May 1982,
Brain research,
L D Pozzo Miller, and
A Aoki
October 1963,
Electroencephalography and clinical neurophysiology,
L D Pozzo Miller, and
A Aoki
August 1978,
Cell and tissue research,
