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Radioimmunodetection (RAID) using Tc-99m labeled Fab' fragments of the anti-CEA monoclonal antibody IMMU-4 was performed in a 68-year-old man for preoperative evaluation of colonic metastases. Planar images at 3 and 18 hours showed uptake within known metastases in the left lobe of the liver that had been observed with CT and at surgery during the preceding month. SPECT images at 3 hours demonstrated two additional unsuspected lesions. All sites were surgically confirmed the following day using intraoperative sonographic guidance, with the smallest occult lesion measuring only 6 x 9 mm. This case illustrates the limitations of CT and surgery, the potential of RAID for the detection of occult metastases, the increased sensitivity of SPECT over planar images for detecting lesions less than 1 cm in diameter, and the value of intraoperative guidance for small nonpalpable lesions.
L C Swayne, and
D M Goldenberg, and
W L Diehl, and
R D Macaulay, and
L A Derby, and
J Z Trivino
January 2000,
Hepato-gastroenterology,
L C Swayne, and
D M Goldenberg, and
W L Diehl, and
R D Macaulay, and
L A Derby, and
J Z Trivino
June 1993,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
L C Swayne, and
D M Goldenberg, and
W L Diehl, and
R D Macaulay, and
L A Derby, and
J Z Trivino
April 1995,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
L C Swayne, and
D M Goldenberg, and
W L Diehl, and
R D Macaulay, and
L A Derby, and
J Z Trivino
January 1991,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
L C Swayne, and
D M Goldenberg, and
W L Diehl, and
R D Macaulay, and
L A Derby, and
J Z Trivino
January 1987,
Cancer detection and prevention,
L C Swayne, and
D M Goldenberg, and
W L Diehl, and
R D Macaulay, and
L A Derby, and
J Z Trivino
March 1995,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
L C Swayne, and
D M Goldenberg, and
W L Diehl, and
R D Macaulay, and
L A Derby, and
J Z Trivino
April 1992,
Nuclear medicine communications,
L C Swayne, and
D M Goldenberg, and
W L Diehl, and
R D Macaulay, and
L A Derby, and
J Z Trivino
August 1985,
Nihon Geka Gakkai zasshi,
L C Swayne, and
D M Goldenberg, and
W L Diehl, and
R D Macaulay, and
L A Derby, and
J Z Trivino
January 1999,
Journal of hepato-biliary-pancreatic surgery,
L C Swayne, and
D M Goldenberg, and
W L Diehl, and
R D Macaulay, and
L A Derby, and
J Z Trivino
July 1990,
Radiology,
