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In a new method for measurement of inactive rat plasma renin, the trypsin generated angiotensin I immunoreactive material, which was HPLC characterized as similar to tetradecapeptide renin substrate, is removed by a cation exchange resin before the renin incubation step. The method also corrects for trypsin destruction of endogenous angiotensinogen by the addition of exogenous angiotensinogen. When measured with this method inactive renin in rat plasma decreased after nephrectomy and increased after adrenalectomy. This is in accordance with findings in humans. A sexual dimorphism of prorenin (inactive renin) in rat plasma, similar to that reported in humans and mice, was demonstrated. Thus, inactive renin in the rat is no exception among species, and the rat might be a suitable animal model for further studies dealing with the physiology of prorenin in plasma and tissues.
K Poulsen, and
A H Nielsen, and
A Johannessen
September 1991,
Canadian journal of physiology and pharmacology,
K Poulsen, and
A H Nielsen, and
A Johannessen
July 1972,
The American journal of physiology,
K Poulsen, and
A H Nielsen, and
A Johannessen
July 1968,
The American journal of physiology,
K Poulsen, and
A H Nielsen, and
A Johannessen
March 1948,
Federation proceedings,
K Poulsen, and
A H Nielsen, and
A Johannessen
September 1969,
Obstetrics and gynecology,
K Poulsen, and
A H Nielsen, and
A Johannessen
January 1963,
Acta pathologica et microbiologica Scandinavica,
K Poulsen, and
A H Nielsen, and
A Johannessen
January 1969,
Verhandlungen der Deutschen Gesellschaft fur Pathologie,
K Poulsen, and
A H Nielsen, and
A Johannessen
April 1965,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K Poulsen, and
A H Nielsen, and
A Johannessen
February 1956,
The American journal of the medical sciences,
K Poulsen, and
A H Nielsen, and
A Johannessen
March 1959,
Endocrinology,
