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Using immunological techniques, we have demonstrated that about half the trypsin-activatable renin in normal rat plasma is prorenin, while the other is not, and that inactive renin in nephrectomized rat plasma is not prorenin. In the present study, the trypsin-induced angiotensin I generating activity not related to prorenin from normal rat plasma disappeared after HPLC on G3000SW. HPLC analysis of trypsin-treated plasma showed the generation of active renin by trypsin for normal rat plasma, while it did not for nephrectomized rat plasma. These results indicate that trypsin treatment of crude plasma results in the generation of angiotensin I generating activity not due to prorenin, as well as activation of prorenin. HPLC on G3000SW is a useful tool for the determination of plasma prorenin.
S Kim, and
M Hosoi, and
K Nakajima, and
K Yamamoto
September 1991,
Canadian journal of physiology and pharmacology,
S Kim, and
M Hosoi, and
K Nakajima, and
K Yamamoto
July 1968,
The American journal of physiology,
S Kim, and
M Hosoi, and
K Nakajima, and
K Yamamoto
February 1984,
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S Kim, and
M Hosoi, and
K Nakajima, and
K Yamamoto
September 1979,
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S Kim, and
M Hosoi, and
K Nakajima, and
K Yamamoto
July 1979,
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S Kim, and
M Hosoi, and
K Nakajima, and
K Yamamoto
January 1962,
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S Kim, and
M Hosoi, and
K Nakajima, and
K Yamamoto
January 1982,
Hypertension (Dallas, Tex. : 1979),
S Kim, and
M Hosoi, and
K Nakajima, and
K Yamamoto
April 1992,
Journal of the Formosan Medical Association = Taiwan yi zhi,
S Kim, and
M Hosoi, and
K Nakajima, and
K Yamamoto
August 1983,
Ugeskrift for laeger,
S Kim, and
M Hosoi, and
K Nakajima, and
K Yamamoto
January 1986,
The American journal of physiology,
