Exposure to phytoestrogens in the perinatal period affects androgen secretion by testicular Leydig cells in the adult rat. 2007

Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
Department of Anatomy, Physiology and Pharmacology, 109 Greene Hall, Auburn University, Auburn, Alabama 36849, USA. akingbt@auburn.edu

The use of soy-based products in the diet of infants has raised concerns regarding the reproductive toxicity of genistein and daidzein, the predominant isoflavones in soybeans with estrogenic activity. Time-bred Long-Evans dams were fed diets containing 0, 5, 50, 500, or 1000 ppm of soy isoflavones from gestational d 12 until weaning at d 21 postpartum. Male rats in all groups were fed soy-free diets from postnatal d 21 until 90 d of age. The mean +/- SD concentration of unconjugated (i.e. biologically active) genistein and daidzein in serum from the group of dams maintained on the diet containing the highest amount of isoflavones (1000 ppm) were 17 +/- 27 and 56 +/- 30 nM, respectively, at d 21 postpartum. The concentrations were considerably greater in male offspring (genistein: 73 +/- 46 nM; daidzein: 106 +/- 53 nM). Although steroidogenesis was decreased in individual Leydig cells, male rats from the highest exposure group (1000 ppm diet) exhibited elevated serum levels of the sex steroid hormones androsterone at 21 d (control: 15 +/- 1.5 vs.28 +/- 3.5 ng/ml; P < 0.05) and testosterone at 90 d of age (control: 7.5 +/- 1 vs.17 +/- 2 ng/ml; P < 0.05). Testosterone secretion by immature Leydig cells, isolated from 35-d-old male rats, decreased on exposure to 0.1 nm genistein in vitro (control: 175 +/- 5 vs. 117 +/- 3 ng/10(6) cells per 24 h; P < 0.05), indicative of direct phytoestrogen action. Thus, phytoestrogens have the ability to regulate Leydig cells, and additional studies to assess potential adverse effects of dietary soy-based products on reproductive tract development in neonates are warranted.

UI MeSH Term Description Entries
D007529 Isoflavones 3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position. 3-Benzylchroman-4-One,3-Benzylidene-4-Chromanone,Homoisoflavone,Homoisoflavones,Isoflavone,Isoflavone Derivative,3-Benzylchroman-4-Ones,3-Benzylidene-4-Chromanones,Isoflavone Derivatives,3 Benzylchroman 4 One,3 Benzylchroman 4 Ones,3 Benzylidene 4 Chromanone,3 Benzylidene 4 Chromanones,Derivative, Isoflavone,Derivatives, Isoflavone
D007985 Leydig Cells Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced. Interstitial Cells, Testicular,Leydig Cell,Testicular Interstitial Cell,Testicular Interstitial Cells,Cell, Leydig,Cell, Testicular Interstitial,Cells, Leydig,Cells, Testicular Interstitial,Interstitial Cell, Testicular
D008297 Male Males
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D005865 Gestational Age The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination. Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages
D000728 Androgens Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power. Androgen,Androgen Receptor Agonist,Androgen Effect,Androgen Effects,Androgen Receptor Agonists,Androgenic Agents,Androgenic Compounds,Agents, Androgenic,Agonist, Androgen Receptor,Agonists, Androgen Receptor,Compounds, Androgenic,Effect, Androgen,Effects, Androgen,Receptor Agonist, Androgen,Receptor Agonists, Androgen
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013737 Testis The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS. Testicles,Testes,Testicle

Related Publications

Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
January 1990, Journal of andrology,
Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
January 2021, Chemosphere,
Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
February 1992, Endocrinology,
Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
June 2002, The Journal of steroid biochemistry and molecular biology,
Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
April 2012, Domestic animal endocrinology,
Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
May 2018, Andrology,
Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
March 1979, Biology of reproduction,
Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
June 1995, The Journal of steroid biochemistry and molecular biology,
Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
April 2006, British poultry science,
Benson T Akingbemi, and Tim D Braden, and Barbara W Kemppainen, and Karen D Hancock, and Jessica D Sherrill, and Sarah J Cook, and Xiaoying He, and Jeffrey G Supko
January 2009, Neurotoxicology and teratology,
Copied contents to your clipboard!