BIOMAT Database Logo BIOMAT Database Logo

Gestational exposure to tebuconazole affects the development of rat fetal Leydig cells. 2021

Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.

Tebuconazole is a triazole fungicide, used in agriculture to treat phytopathogenic fungi, and as a biocide, has been reported to be related to reproductive and developmental toxicity. The purpose of this study was to investigate the effect of tebuconazole exposure on rat fetal Leydig cells and fetal testis during pregnancy. Pregnant Sprague-Dawley rats were randomly divided into 4 groups, daily gavaged with corn oil (as a control), 25, 50, and 100 mg/kg body weight tebuconazole for 10 days (from the 12th day of pregnancy). Tebuconazole increased fetal serum testosterone and progesterone levels at a dose of 100 mg/kg. Exposure to 100 mg/kg tebuconazole significantly caused an increase in the number of fetal Leydig cells per testis without inducing cell aggregation. Tebuconazole up-regulated the expression of Star, Cyp11a1, Hsd17b3, and Fshr and their proteins. Further investigation found that tebuconazole caused increased phosphorylation of AKT1, ERK1/2, and mTOR, the level of BCL2, as well as the decrease of Beclin1, LC3B, and BAX, which may contribute to the fetal Leydig cell autophagy and proliferation. In conclusion, in utero exposure of tebuconazole causes the proliferation of fetal Leydig cells.

UI MeSH Term Description Entries
D007985 Leydig Cells Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced. Interstitial Cells, Testicular,Leydig Cell,Testicular Interstitial Cell,Testicular Interstitial Cells,Cell, Leydig,Cell, Testicular Interstitial,Cells, Leydig,Cells, Testicular Interstitial,Interstitial Cell, Testicular
D008297 Male Males
D010750 Phosphoproteins Phosphoprotein
D010766 Phosphorylation The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety. Phosphorylations
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011297 Prenatal Exposure Delayed Effects The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH. Delayed Effects, Prenatal Exposure,Late Effects, Prenatal Exposure
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D012098 Reproduction The total process by which organisms produce offspring. (Stedman, 25th ed) Human Reproductive Index,Human Reproductive Indexes,Reproductive Period,Human Reproductive Indices,Index, Human Reproductive,Indexes, Human Reproductive,Indices, Human Reproductive,Period, Reproductive,Periods, Reproductive,Reproductive Index, Human,Reproductive Indices, Human,Reproductive Periods
D005260 Female Females
D005659 Fungicides, Industrial Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc. Industrial Fungicides

Related Publications

Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
Gestational exposure to tetrabutyltin blocks rat fetal Leydig cell development.
June 2018, Reproductive toxicology (Elmsford, N.Y.),
Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells.
February 2016, International journal of environmental research and public health,
Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells.
January 2014, PloS one,
Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
The fate of fetal Leydig cells during the development of the fetal and postnatal rat testis.
July 1988, Development (Cambridge, England),
Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
Development of fetal and adult Leydig cells.
October 2019, Reproductive medicine and biology,
Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
Exposure to phytoestrogens in the perinatal period affects androgen secretion by testicular Leydig cells in the adult rat.
September 2007, Endocrinology,
Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
Effects of gestational Perfluorooctane Sulfonate exposure on the developments of fetal and adult Leydig cells in F1 males.
July 2020, Environmental pollution (Barking, Essex : 1987),
Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
Exposure to cadmium during gestation and lactation affects development and function of Leydig cells in male offspring.
March 2018, Environmental toxicology,
Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
Development of transmembrane signaling in the fetal rat Leydig cell.
January 1989, Journal of andrology,
Feifei Ma, and Yang Li, and Yige Yu, and Zengqiang Li, and Liben Lin, and Quanxu Chen, and Qiang Xu, and Peipei Pan, and Yiyan Wang, and Ren-Shan Ge
Development, function and fate of fetal Leydig cells.
November 2016, Seminars in cell & developmental biology,
Copied contents to your clipboard!