BIOMAT Database Logo BIOMAT Database Logo

Effects of melatonin on [3H]-thymidine incorporation into DNA of rat thyroid lobes in vitro. 1991

E Wajs, and A Lewiński
Laboratory of Thyrology, Institute of Endocrinology, University School of Medicine, Lódź, Poland.

The effects of 4-h incubation in the presence of melatonin and N-acetylserotonin on the incorporation of [3H]-thymidine into DNA of the rat thyroid lobes were investigated. Additionally, thyroid lobes were incubated in the exposure to melatonin with thyrotropin jointly. Melatonin, when applied in the lowest concentration examined (10(-9)M), inhibited [3H]-thymidine incorporation, the effect of other concentrations (10(-6)M-10(-8)M) being not significant. N-acetylserotonin (10(-6)M) did not affect the rate of incorporation of that labelled nucleoside. As expected, thyrotropin enhanced the [3H]-thymidine incorporation into DNA of thyroid lobes. Melatonin (10(-7)M) suppressed that stimulatory effect of thyrotropin. The participation of melatonin in the regulation of thyroid growth processes is considered.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008297 Male Males
D008550 Melatonin A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
D009924 Organ Culture Techniques A technique for maintenance or growth of animal organs in vitro. It refers to three-dimensional cultures of undisaggregated tissue retaining some or all of the histological features of the tissue in vivo. (Freshney, Culture of Animal Cells, 3d ed, p1) Organ Culture,Culture Technique, Organ,Culture Techniques, Organ,Organ Culture Technique,Organ Cultures
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D004261 DNA Replication The process by which a DNA molecule is duplicated. Autonomous Replication,Replication, Autonomous,Autonomous Replications,DNA Replications,Replication, DNA,Replications, Autonomous,Replications, DNA
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012701 Serotonin A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator. 5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine

Related Publications

E Wajs, and A Lewiński
Effects of calcitonin and calcitonin gene-related peptide on 3H-thymidine incorporation into DNA of rat thyroid lobes in vitro.
January 1992, Cytobios,
E Wajs, and A Lewiński
Increased incorporation of 3H-thymidine into rat liver DNA after handling of liver lobes.
December 1969, British journal of experimental pathology,
E Wajs, and A Lewiński
Changes of 3H-thymidine incorporation into DNA and thymidine kinase activity in rat thyroid lobes, following their exposure to neuropeptide Y.
January 1994, Cytobios,
E Wajs, and A Lewiński
Inhibitory effect of somatostatin on the basal and TSH-stimulated 3H-thymidine incorporation into rat thyroid lobes incubated in vitro.
July 1988, Biochemical and biophysical research communications,
E Wajs, and A Lewiński
Effects of thymulin on in vitro incorporation of 3H-thymidine into gonocytes of newborn rat testes.
January 1994, Reproduction, nutrition, development,
E Wajs, and A Lewiński
Effects of nickel compounds on incorporation of [3H] thymidine into DNA in rat liver and kidney.
April 1980, Carcinogenesis,
E Wajs, and A Lewiński
Effects of FSH and LH on incorporation of [3H]thymidine into follicular DNA.
September 1986, Journal of reproduction and fertility,
E Wajs, and A Lewiński
[Factors affecting 3H-thymidine incorporation into cells synthesizing DNA].
January 1986, Eksperimental'naia onkologiia,
E Wajs, and A Lewiński
In-vitro incorporation of [3H]thymidine by diapausing rat blastocysts.
September 1976, Journal of reproduction and fertility,
E Wajs, and A Lewiński
The effects of testosterone administered neonatally on the incorporation of 3H-leucine into protein and 3H-thymidine into dna in the ventral prostate of rat.
May 1974, Endokrinologie,
Copied contents to your clipboard!