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The effects of somatostatin on the spontaneous and TSH--stimulated incorporation of tritiated thymidine into the rat thyroid lobes incubated in vitro were investigated. The rate of 3H-thymidine incorporation was used as an index of thyroid follicular cells (TFC) proliferation. It was shown that: 1) somatostatin, at a concentration of 10(-7)M, decreased 3H-thymidine incorporation into DNA of TFC, 2) the highest somatostatin concentration, as tested in this study (10(-6)M), produced a similar decreasing effect; the decrease, in this case, did not attain significance vs. controls, 3) somatostatin, when employed together with TSH, suppressed the stimulatory effect of the latter hormone on 3H-thymidine incorporation into DNA of thyroid lobes.
G Zerek-Mełeń, and
A Lewiński
December 1991,
Biochemical and biophysical research communications,
G Zerek-Mełeń, and
A Lewiński
January 1992,
Cytobios,
G Zerek-Mełeń, and
A Lewiński
January 1994,
Cytobios,
G Zerek-Mełeń, and
A Lewiński
December 1969,
British journal of experimental pathology,
G Zerek-Mełeń, and
A Lewiński
January 1975,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
G Zerek-Mełeń, and
A Lewiński
February 1987,
Endocrinologia japonica,
G Zerek-Mełeń, and
A Lewiński
May 1985,
Zhong yao tong bao (Beijing, China : 1981),
G Zerek-Mełeń, and
A Lewiński
February 1978,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
G Zerek-Mełeń, and
A Lewiński
January 1975,
Acta biochimica et biophysica; Academiae Scientiarum Hungaricae,
G Zerek-Mełeń, and
A Lewiński
January 1973,
Dermatologica,
