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Subdermal silastic implants releasing norethindrone acetate were inserted in five rhesus monkeys for a period of seven months. The serum norethindrone (NET) levels were estimated from blood samples collected fortnightly. There was an initial high level of NET followed by fluctuating levels of NET in 4 out of five monkeys. The serum NET values showed individual variation between time periods as well as between monkeys. The analysis of menstrual cycles showed initial amenorrhoea up to day 120-140 in four out of five monkeys. Only one monkey showed vaginal bleeding pattern comparable to normal menstrual cycles; this monkey had serum NET levels less than 10 ng/ml. The pharmacokinetic and pharmacodynamic parameters were similar to those reported in the human female.
P Jha, and
K Murugesan, and
A Farooq
October 1980,
Endocrinologia japonica,
P Jha, and
K Murugesan, and
A Farooq
January 1991,
Yao xue xue bao = Acta pharmaceutica Sinica,
P Jha, and
K Murugesan, and
A Farooq
February 1982,
Acta endocrinologica,
P Jha, and
K Murugesan, and
A Farooq
December 1978,
Contraception,
P Jha, and
K Murugesan, and
A Farooq
March 1974,
Contraception,
P Jha, and
K Murugesan, and
A Farooq
February 1978,
Indian journal of experimental biology,
P Jha, and
K Murugesan, and
A Farooq
January 1985,
Arzneimittel-Forschung,
P Jha, and
K Murugesan, and
A Farooq
January 1983,
Acta obstetricia et gynecologica Scandinavica,
P Jha, and
K Murugesan, and
A Farooq
January 1967,
American journal of obstetrics and gynecology,
P Jha, and
K Murugesan, and
A Farooq
October 1969,
Indian journal of experimental biology,
