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The metabolic clearance rate (MCR) of norethindrone acetate (NETA) and norethindrone (NET) levels in plasma were studied after an iv injection of [3H]NETA in three women before and at 1 week, 1, 2 and 6 months following the insertion of a single silastic subdermal implant releasing microquantities of NETA. No significant change in the MCR of NETA was observed at 1 week (459 +/- 72 1/day), 1 month (489 +/- 113 1/day) and 2 months (522 +/- 144 1/day) compared with that of control (525 +/- 108 1/day). However, MCR of NETA showed significant increase in women exposed to continuous presence of NETA for a period of 6 months (608 +/- 121 1/day; P less than 0.025). NETA was rapidly and extensively metabolized into NET. At 1 week, 1, 2 and 6 months of study, NET was observed to be present in higher amounts compared with NETA. The production rate (PR) of progesterone decreased significantly at 2 and 6 months of NETA implant insertion compared with the PR before the insertion of implant.
H Singh, and
J P Uniyal, and
P Jha, and
D Takker, and
K Murguesan, and
V Hingorani, and
K R Laumas
December 1978,
Contraception,
H Singh, and
J P Uniyal, and
P Jha, and
D Takker, and
K Murguesan, and
V Hingorani, and
K R Laumas
April 1977,
Contraception,
H Singh, and
J P Uniyal, and
P Jha, and
D Takker, and
K Murguesan, and
V Hingorani, and
K R Laumas
February 1981,
Contraception,
H Singh, and
J P Uniyal, and
P Jha, and
D Takker, and
K Murguesan, and
V Hingorani, and
K R Laumas
October 1977,
Contraception,
H Singh, and
J P Uniyal, and
P Jha, and
D Takker, and
K Murguesan, and
V Hingorani, and
K R Laumas
May 1986,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
H Singh, and
J P Uniyal, and
P Jha, and
D Takker, and
K Murguesan, and
V Hingorani, and
K R Laumas
February 1979,
Contraception,
H Singh, and
J P Uniyal, and
P Jha, and
D Takker, and
K Murguesan, and
V Hingorani, and
K R Laumas
April 1978,
Contraception,
H Singh, and
J P Uniyal, and
P Jha, and
D Takker, and
K Murguesan, and
V Hingorani, and
K R Laumas
September 1991,
Contraception,
H Singh, and
J P Uniyal, and
P Jha, and
D Takker, and
K Murguesan, and
V Hingorani, and
K R Laumas
January 1977,
Contraception,
H Singh, and
J P Uniyal, and
P Jha, and
D Takker, and
K Murguesan, and
V Hingorani, and
K R Laumas
April 1978,
Contraception,
