Effect of oxytocin on acupuncture analgesia in the rat. 2007

Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co. Ltd., Jianghai Distract, Jiangmen, Guangdong 529080, China. yj6676@yahoo.com

Oxytocin has been demonstrated to be involved in pain modulation. Acupuncture analgesia is a very useful clinical tool for pain relief, which has over 2500-year history in China. The present study investigated the role of oxytocin in acupuncture analgesia in the rat through oxytocin administration and measurement. Central administration of oxytocin (intraventricular injection or intrathecal injection) enhanced acupuncture analgesia, while central administration of anti-oxytocin serum weakened acupuncture analgesia in a dose-dependent manner. However, intravenous injection of oxytocin or anti-oxytocin serum did not influence acupuncture analgesia. Electrical acupuncture of "Zusanli" (St. 36) reduced oxytocin concentration in the hypothalamic supraoptic nucleus, and elevated oxytocin concentration in the hypothalamic suprachiasmatic nucleus, hypothalamic ventromedial nucleus, thalamic ventral nucleus, periaqueductal gray, raphe magnus nucleus, caudate nucleus, thoracic spinal cord and lumbar spinal cord, but did not alter oxytocin concentration in the hypothalamic paraventricular nucleus, anterior pituitary, posterior pituitary and plasma. The data suggested that oxytocin in central nervous system rather than in peripheral organs is involved in acupuncture analgesia.

UI MeSH Term Description Entries
D007276 Injections, Intraventricular Injections into the cerebral ventricles. Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D007278 Injections, Spinal Introduction of therapeutic agents into the spinal region using a needle and syringe. Injections, Intraspinal,Injections, Intrathecal,Intraspinal Injections,Intrathecal Injections,Spinal Injections,Injection, Intraspinal,Injection, Intrathecal,Injection, Spinal,Intraspinal Injection,Intrathecal Injection,Spinal Injection
D008297 Male Males
D010121 Oxytocin A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION. Ocytocin,Pitocin,Syntocinon
D010146 Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D010902 Pituitary Gland A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM. Hypophysis,Hypothalamus, Infundibular,Infundibular Stalk,Infundibular Stem,Infundibulum (Hypophysis),Infundibulum, Hypophyseal,Pituitary Stalk,Hypophyseal Infundibulum,Hypophyseal Stalk,Hypophysis Cerebri,Infundibulum,Cerebri, Hypophysis,Cerebrus, Hypophysis,Gland, Pituitary,Glands, Pituitary,Hypophyseal Stalks,Hypophyses,Hypophysis Cerebrus,Infundibular Hypothalamus,Infundibular Stalks,Infundibulums,Pituitary Glands,Pituitary Stalks,Stalk, Hypophyseal,Stalk, Infundibular,Stalks, Hypophyseal,Stalks, Infundibular
D002552 Cerebral Ventricles Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE). Foramen of Monro,Cerebral Ventricular System,Cerebral Ventricle,Cerebral Ventricular Systems,Monro Foramen,System, Cerebral Ventricular,Systems, Cerebral Ventricular,Ventricle, Cerebral,Ventricles, Cerebral,Ventricular System, Cerebral,Ventricular Systems, Cerebral
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D000698 Analgesia Methods of PAIN relief that may be used with or in place of ANALGESICS. Analgesias
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
January 1992, Zhen ci yan jiu = Acupuncture research,
Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
January 1986, Zhen ci yan jiu = Acupuncture research,
Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
January 1989, Zhen ci yan jiu = Acupuncture research,
Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
November 1980, Brain research,
Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
January 1988, Zhen ci yan jiu = Acupuncture research,
Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
January 1978, Advances in biochemical psychopharmacology,
Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
January 2000, The American journal of Chinese medicine,
Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
January 1989, Farmakologiia i toksikologiia,
Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
August 1979, Chinese medical journal,
Jun Yang, and Yu Yang, and Jian-Min Chen, and Wen-Yan Liu, and Cheng-Hai Wang, and Bao-Cheng Lin
October 2013, JAMA,
Copied contents to your clipboard!