Biomaterial Database

[Effect of ketamine on acupuncture analgesia]. 1989

W Xu, and Y S Yan, and Z Q Chen

There were different opinions about whether ketamine has an antagonistic effect on electroacupuncture (EA) analgesia. The aim of this paper was to investigate the effect of ketamine on EA. The rats were divided into three groups: 4 mg/kg, 20 mg/kg of ketamine in doses, and normal saline groups. Ketamine was injected peritoneally in dosage of 4 mg/kg and 20 mg/kg respectively. Tail flick latency (TFL) and vocalization threshold (VT) were taken as the indices of pain responses. Changqiang and Yaoshu acupoints were selected for electroacupuncture. It was observed that the analgesia effects of EA were attenuated after injection of ketamine either in 4 mg/kg group of 20 mg/kg group. The results indicate that 4 mg/kg or 20 mg/kg ketamine in doses has an antagonistic effect on EA analgesia, suggesting that attention should be paid to the dosage when ketamine is used for EA analgesia.

UI	MeSH Term	Description	Entries
D007649	Ketamine	A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.	2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone,CI-581,Calipsol,Calypsol,Kalipsol,Ketalar,Ketamine Hydrochloride,Ketanest,Ketaset,CI 581,CI581
D008297	Male		Males
D010146	Pain	An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012684	Sensory Thresholds	The minimum amount of stimulus energy necessary to elicit a sensory response.	Sensory Threshold,Threshold, Sensory,Thresholds, Sensory
D015667	Acupuncture Analgesia	Analgesia produced by the insertion of ACUPUNCTURE needles at certain ACUPUNCTURE POINTS on the body. This activates small myelinated nerve fibers in the muscle which transmit impulses to the spinal cord and then activate three centers - the spinal cord, midbrain and pituitary/hypothalamus - to produce analgesia.	Analgesia, Acupuncture,Acupuncture Anesthesia,Anesthesia, Acupuncture
D015671	Electroacupuncture	A form of acupuncture with electrical impulses passing through the needles to stimulate NERVE TISSUE. It can be used for ANALGESIA; ANESTHESIA; REHABILITATION; and treatment for diseases.
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus