-transparent.png){kind=logo}
Cassia siamea L. (Fabaceae) was identified from the southwest Nigerian ethnobotany as a remedy for febrile illness. This led to the bioassay-guided fractionation of stem bark of the plant extract, using the parasite lactate dehydrogenase assay and multi-resistant strain of Plasmodium falciparum (K1) for assessing the in vitro antimalarial activity. Emodin and lupeol were isolated from the ethyl acetate fraction by a combination of chromatographic techniques. The structures of the compounds were determined by spectroscopy, co-spotting with authentic samples and comparison with literature data. Both compounds were found to be the active principles responsible for the antiplasmodial property with IC(50) values of 5 microg/mL, respectively.
E O Ajaiyeoba, and
J S Ashidi, and
L C Okpako, and
P J Houghton, and
C W Wright
August 2007,
Organic letters,
E O Ajaiyeoba, and
J S Ashidi, and
L C Okpako, and
P J Houghton, and
C W Wright
October 2009,
Journal of natural products,
E O Ajaiyeoba, and
J S Ashidi, and
L C Okpako, and
P J Houghton, and
C W Wright
January 2010,
Journal of ethnopharmacology,
E O Ajaiyeoba, and
J S Ashidi, and
L C Okpako, and
P J Houghton, and
C W Wright
November 2012,
Journal of natural products,
E O Ajaiyeoba, and
J S Ashidi, and
L C Okpako, and
P J Houghton, and
C W Wright
April 2001,
Phytochemistry,
E O Ajaiyeoba, and
J S Ashidi, and
L C Okpako, and
P J Houghton, and
C W Wright
March 2015,
Journal of ethnopharmacology,
E O Ajaiyeoba, and
J S Ashidi, and
L C Okpako, and
P J Houghton, and
C W Wright
August 2002,
Chemical & pharmaceutical bulletin,
E O Ajaiyeoba, and
J S Ashidi, and
L C Okpako, and
P J Houghton, and
C W Wright
January 2010,
Biological & pharmaceutical bulletin,
E O Ajaiyeoba, and
J S Ashidi, and
L C Okpako, and
P J Houghton, and
C W Wright
January 2022,
African journal of infectious diseases,
E O Ajaiyeoba, and
J S Ashidi, and
L C Okpako, and
P J Houghton, and
C W Wright
April 1996,
Planta medica,
