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Antiviral chromones from the stem of Cassia siamea. 2012
Qiu-Fen Hu, and
Bin Zhou, and
Xue-Mei Gao, and
Li-Ying Yang, and
Li-Dan Shu, and
Yanqiong Shen, and
Gan-Peng Li, and
Chun-Tao Che, and
Guang-Yu Yang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities , Kunming 650031, Yunnan, People's Republic of China.
Seven new chromones, siamchromones A-G (1-7), and 12 known chromones (8-19) were isolated from the stems of Cassia siamea. Compounds 1-19 were evaluated for their antitobacco mosaic virus (anti-TMV) and anti-HIV-1 activities. Compound 6 showed antitobacco mosaic virus (anti-TMV) activity with an inhibition rate of 35.3% and IC50 value of 31.2 μM, which is higher than that of the positive control, ningnamycin. Compounds 1, 10, 13, and 16 showed anti-TMV activities with inhibition rates above 10%. Compounds 4, 6, 13, and 19 showed anti-HIV-1 activities with therapeutic index values above 50.
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