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Pancreastatin, a 49-amino-acid C-terminal amidated peptide, was isolated from porcine pancreas in 1986. It has been reported to inhibit insulin release and exocrine pancreatic secretion, but both these effects have been disputed. In the isolated perfused rat pancreas we therefore studied the effect of pancreastatin on insulin and exocrine pancreatic secretion. Neither basal exocrine pancreatic secretion, nor exocrine secretion stimulated by CCK-8, bombesin or secretin were affected by pancreastatin. 20 or 200 pM pancreastatin, however, significantly inhibited stimulated insulin release. We conclude that pancreastatin seems to be yet another inhibitory peptide, which--for unknown reasons--inhibits insulin release both in vivo and in vitro, but exocrine pancreatic secretion only in vivo.
J von Schönfeld, and
M K Müller, and
I Neisius, and
M Geling, and
M Rünzi, and
H Goebell
June 1990,
Diabetes research (Edinburgh, Scotland),
J von Schönfeld, and
M K Müller, and
I Neisius, and
M Geling, and
M Rünzi, and
H Goebell
January 1989,
Pancreas,
J von Schönfeld, and
M K Müller, and
I Neisius, and
M Geling, and
M Rünzi, and
H Goebell
June 1999,
Journal of gastroenterology and hepatology,
J von Schönfeld, and
M K Müller, and
I Neisius, and
M Geling, and
M Rünzi, and
H Goebell
June 1989,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
J von Schönfeld, and
M K Müller, and
I Neisius, and
M Geling, and
M Rünzi, and
H Goebell
May 1989,
Regulatory peptides,
J von Schönfeld, and
M K Müller, and
I Neisius, and
M Geling, and
M Rünzi, and
H Goebell
November 1988,
Biochemical and biophysical research communications,
J von Schönfeld, and
M K Müller, and
I Neisius, and
M Geling, and
M Rünzi, and
H Goebell
August 1995,
Pancreas,
J von Schönfeld, and
M K Müller, and
I Neisius, and
M Geling, and
M Rünzi, and
H Goebell
January 1968,
Acta chirurgica Italica,
J von Schönfeld, and
M K Müller, and
I Neisius, and
M Geling, and
M Rünzi, and
H Goebell
January 1988,
Life sciences,
J von Schönfeld, and
M K Müller, and
I Neisius, and
M Geling, and
M Rünzi, and
H Goebell
September 1996,
Acta physiologica Scandinavica,
