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Pancreastatin is a novel peptide that was recently purified from extracts of the porcine pancreas. The present study shows that pancreastatin (10(-9)-10(-8) M) can stimulate release of insulin from both the isolated perfused rat pancreas and from cultured rat islet cells in the presence of a low, non-insulinotropic concentration of glucose (4.2 mM). Pancreastatin (10(-9) M) can also inhibit release of insulin stimulated by a high concentration of glucose (16.7 mM). Pancreastatin, at 10(-8) M, can enhance glucose (8.3 mM) induced release of insulin in the static islet cell incubation. In addition, pancreastatin (10(-9)-10(-8) M) can inhibit, in a dose-dependent fashion, cholecystokinin (CCK)-8 stimulated release of amylase from dispersed guinea pig pancreatic acini. Pancreastatin alone, however, did not affect basal release of amylase. Our study shows that pancreastatin can exert a direct effect on both pancreatic endocrine and exocrine secretion.
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I Asada, and
G J Poston, and
F Lluis, and
K Tatemoto, and
G H Greeley, and
J C Thompson
June 1989,
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J Ishizuka, and
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F Lluis, and
K Tatemoto, and
G H Greeley, and
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May 1989,
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G H Greeley, and
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October 1991,
Scandinavian journal of gastroenterology,
J Ishizuka, and
I Asada, and
G J Poston, and
F Lluis, and
K Tatemoto, and
G H Greeley, and
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January 1989,
Digestion,
J Ishizuka, and
I Asada, and
G J Poston, and
F Lluis, and
K Tatemoto, and
G H Greeley, and
J C Thompson
June 1990,
Diabetes research (Edinburgh, Scotland),
J Ishizuka, and
I Asada, and
G J Poston, and
F Lluis, and
K Tatemoto, and
G H Greeley, and
J C Thompson
June 1999,
Journal of gastroenterology and hepatology,
J Ishizuka, and
I Asada, and
G J Poston, and
F Lluis, and
K Tatemoto, and
G H Greeley, and
J C Thompson
April 1990,
Regulatory peptides,
J Ishizuka, and
I Asada, and
G J Poston, and
F Lluis, and
K Tatemoto, and
G H Greeley, and
J C Thompson
December 1990,
Gastroenterology,
J Ishizuka, and
I Asada, and
G J Poston, and
F Lluis, and
K Tatemoto, and
G H Greeley, and
J C Thompson
September 2013,
Current opinion in gastroenterology,
J Ishizuka, and
I Asada, and
G J Poston, and
F Lluis, and
K Tatemoto, and
G H Greeley, and
J C Thompson
October 1991,
Zeitschrift fur Gastroenterologie,
