Biomaterial Database

Construction of the zona pellucida during production of fertilizable mouse eggs. 1991

P M Wassarman

Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110.

All mammalian eggs are surrounded by a thick extracellular coat, or zona pellucida. Construction of the zona pellucida is an essential step during the production of fertilizable mammalian eggs. Zona pellucida glycoproteins are synthesized exclusively by oocytes during their growth phase and are then assembled in a highly specific manner into a thick extracellular coat. These unique glycoproteins play important roles during mammalian oogenesis, fertilization, and preimplantation development. Consequently, construction of the zona pellucida is a major activity of growing oocytes as they prepare for ovulation and fertilization.

UI	MeSH Term	Description	Entries
D009865	Oocytes	Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).	Ovocytes,Oocyte,Ovocyte
D006023	Glycoproteins	Conjugated protein-carbohydrate compounds including MUCINS; mucoid, and AMYLOID glycoproteins.	C-Glycosylated Proteins,Glycosylated Protein,Glycosylated Proteins,N-Glycosylated Proteins,O-Glycosylated Proteins,Glycoprotein,Neoglycoproteins,Protein, Glycosylated,Proteins, C-Glycosylated,Proteins, Glycosylated,Proteins, N-Glycosylated,Proteins, O-Glycosylated
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015044	Zona Pellucida	A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.
D015870	Gene Expression	The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.	Expression, Gene,Expressions, Gene,Gene Expressions
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

P M Wassarman

Properties of the zona pellucida of cytochalasin B-induced triploid mouse eggs.

March 1985, Journal of reproduction and fertility,

P M Wassarman

Transfer to the mouse oviduct of eggs with and without the zona pellucida.

June 1970, Journal of reproduction and fertility,

P M Wassarman

Softening of the mouse zona pellucida during oocyte maturation.

January 2013, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,

P M Wassarman

Cell fusion induced by a virus within the zona pellucida of mouse eggs.

March 1973, Nature,

P M Wassarman

The role of the zona pellucida in the development of mouse eggs in vivo.

June 1970, Journal of embryology and experimental morphology,

P M Wassarman

Oocyte proteomics: localisation of mouse zona pellucida protein 3 to the plasma membrane of ovulated mouse eggs.

January 2004, Reproduction, fertility, and development,

P M Wassarman

Fertilization of mouse and human eggs by microinjection of single spermatozoa under the zona pellucida.

January 1989, Journal of reproduction and fertility. Supplement,