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The eukaryotic cell division cycle depends on an intricate sequence of transcriptional events. Using an algorithm based on maximum-entropy deconvolution, and expression data from a highly synchronized yeast culture, we have timed the peaks of expression of transcriptionally regulated cell cycle genes to an accuracy of 2 min (approximately equal to 1% of the cell cycle time). The set of 1,129 cell cycle-regulated genes was identified by a comprehensive analysis encompassing all available cell cycle yeast data sets. Our results reveal distinct subphases of the cell cycle undetectable by morphological observation, as well as the precise timeline of macromolecular complex assembly during key cell cycle events.
Maga Rowicka, and
Andrzej Kudlicki, and
Benjamin P Tu, and
Zbyszek Otwinowski
November 2002,
The Journal of biological chemistry,
Maga Rowicka, and
Andrzej Kudlicki, and
Benjamin P Tu, and
Zbyszek Otwinowski
January 2011,
Advances in genetics,
Maga Rowicka, and
Andrzej Kudlicki, and
Benjamin P Tu, and
Zbyszek Otwinowski
March 1992,
Trends in genetics : TIG,
Maga Rowicka, and
Andrzej Kudlicki, and
Benjamin P Tu, and
Zbyszek Otwinowski
January 1990,
Developmental genetics,
Maga Rowicka, and
Andrzej Kudlicki, and
Benjamin P Tu, and
Zbyszek Otwinowski
August 1996,
The American journal of pathology,
Maga Rowicka, and
Andrzej Kudlicki, and
Benjamin P Tu, and
Zbyszek Otwinowski
June 2017,
Journal of visualized experiments : JoVE,
Maga Rowicka, and
Andrzej Kudlicki, and
Benjamin P Tu, and
Zbyszek Otwinowski
August 2009,
PLoS computational biology,
Maga Rowicka, and
Andrzej Kudlicki, and
Benjamin P Tu, and
Zbyszek Otwinowski
April 2010,
Developmental cell,
Maga Rowicka, and
Andrzej Kudlicki, and
Benjamin P Tu, and
Zbyszek Otwinowski
January 2006,
Molecular cell,
Maga Rowicka, and
Andrzej Kudlicki, and
Benjamin P Tu, and
Zbyszek Otwinowski
February 2017,
The EMBO journal,
