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To evaluate pharmacokinetics and clinical efficacy of flomoxef (6315-S, FMOX) in neonates, FMOX was administered to 21 neonates. With 20 mg/kg and 40 mg/kg of intravenous drip-infusion of FMOX 60 minutes, half lives (T 1/2's) was 64.9 minutes and 130.3 minutes, respectively, and when 20 mg/kg of FMOX was infused intravenously to 2 cases, half lives were 70.8 minutes and 110.1 minutes, respectively. When 45-100 mg/kg of FMOX was administered to 17 neonates with infections (pneumonia 8, sepsis 1, sepsis suspected 2, intrauterine infection 2, urinary tract infection 2, omphalitis 2), the efficacy rate was 88.2% (15 of 17). No adverse reactions were observed clinically in the 21 neonates. Transient elevation of eosinophilia was observed in 1 case and transient elevation of S-GOT and S-GPT 1 in another. These results suggest that FMOX is an effective and safe antibiotic to use in neonates.
T Ihara, and
H Kamiya, and
T Matsuda, and
S Shimizu, and
H Nishi, and
H Inamochi, and
N Taki, and
M Suzuki, and
M Kojima, and
H Kawasaki
November 1991,
The Japanese journal of antibiotics,
T Ihara, and
H Kamiya, and
T Matsuda, and
S Shimizu, and
H Nishi, and
H Inamochi, and
N Taki, and
M Suzuki, and
M Kojima, and
H Kawasaki
November 1991,
The Japanese journal of antibiotics,
T Ihara, and
H Kamiya, and
T Matsuda, and
S Shimizu, and
H Nishi, and
H Inamochi, and
N Taki, and
M Suzuki, and
M Kojima, and
H Kawasaki
March 1988,
The Japanese journal of antibiotics,
T Ihara, and
H Kamiya, and
T Matsuda, and
S Shimizu, and
H Nishi, and
H Inamochi, and
N Taki, and
M Suzuki, and
M Kojima, and
H Kawasaki
July 1993,
The Japanese journal of antibiotics,
T Ihara, and
H Kamiya, and
T Matsuda, and
S Shimizu, and
H Nishi, and
H Inamochi, and
N Taki, and
M Suzuki, and
M Kojima, and
H Kawasaki
March 1988,
The Japanese journal of antibiotics,
T Ihara, and
H Kamiya, and
T Matsuda, and
S Shimizu, and
H Nishi, and
H Inamochi, and
N Taki, and
M Suzuki, and
M Kojima, and
H Kawasaki
November 1991,
The Japanese journal of antibiotics,
T Ihara, and
H Kamiya, and
T Matsuda, and
S Shimizu, and
H Nishi, and
H Inamochi, and
N Taki, and
M Suzuki, and
M Kojima, and
H Kawasaki
October 1987,
The Japanese journal of antibiotics,
T Ihara, and
H Kamiya, and
T Matsuda, and
S Shimizu, and
H Nishi, and
H Inamochi, and
N Taki, and
M Suzuki, and
M Kojima, and
H Kawasaki
March 1988,
The Japanese journal of antibiotics,
T Ihara, and
H Kamiya, and
T Matsuda, and
S Shimizu, and
H Nishi, and
H Inamochi, and
N Taki, and
M Suzuki, and
M Kojima, and
H Kawasaki
June 1991,
The Japanese journal of antibiotics,
T Ihara, and
H Kamiya, and
T Matsuda, and
S Shimizu, and
H Nishi, and
H Inamochi, and
N Taki, and
M Suzuki, and
M Kojima, and
H Kawasaki
November 1991,
The Japanese journal of antibiotics,
