Biomaterial Database

Spermatids are regulators of Sertoli cell function. 1991

B Jégou

Groupe d'Etude de la Reproduction chez le Mâle, INSERM/CJF 91-04, Université de Rennes I, France.

Spermatids are major regulators of Sertoli cell function. Specific anatomical structures exist between spermatids and Sertoli cells. Their nature evolves during spermiogenesis and they are essential mediators in the interaction between these two cell types. Spermatids play a crucial role in Sertoli cell gene expression and secretory function at different ages. Early spermatid effect is partly mediated through the secretion of soluble factor(s). The influence of late spermatids on Sertoli cell secretion in the adult testis is conserved throughout evolution and may be mediated via their implication in the conformational changes on Sertoli cells that occur during spermatogenesis and through phagocytosis of the residual bodies.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002450	Cell Communication	Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.	Cell Interaction,Cell-to-Cell Interaction,Cell Communications,Cell Interactions,Cell to Cell Interaction,Cell-to-Cell Interactions,Communication, Cell,Communications, Cell,Interaction, Cell,Interaction, Cell-to-Cell,Interactions, Cell,Interactions, Cell-to-Cell
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012708	Sertoli Cells	Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete the ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.	Sertoli Cell,Cell, Sertoli,Cells, Sertoli
D013087	Spermatids	Male germ cells derived from the haploid secondary SPERMATOCYTES. Without further division, spermatids undergo structural changes and give rise to SPERMATOZOA.	Spermatoblasts,Spermatid,Spermatoblast