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Novel drug resistance pattern associated with the mutations K70G and M184V in human immunodeficiency virus type 1 reverse transcriptase. 2007
D Bradshaw, and
S Malik, and
C Booth, and
M Van Houtte, and
T Pattery, and
A Waters, and
J Ainsworth, and
A M Geretti
Department of Virology, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom.
We describe an unusual pathway of human immunodeficiency virus type 1 reverse transcriptase resistance during therapy with tenofovir-emtricitabine, characterized initially by the mutations K70E and M184V and later by K70G and M184V, with the two mutations coexisting on the same viral genome. Phenotypic resistance to lamivudine, emtricitabine, abacavir, didanosine, and tenofovir was observed, whereas susceptibility to zidovudine and stavudine was preserved.
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