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Multiple effects of the M184V resistance mutation in the reverse transcriptase of human immunodeficiency virus type 1. 2003

Dan Turner, and Bluma Brenner, and Mark A Wainberg
McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.

UI MeSH Term Description Entries
D004351 Drug Resistance Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration. Resistance, Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D054303 HIV Reverse Transcriptase A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process. Reverse Transcriptase, HIV,Reverse Transcriptase, Human Immunodeficiency Virus,Transcriptase, HIV Reverse
D018406 Virus Physiological Phenomena Biological properties, processes, and activities of VIRUSES, including the interactions with the cells they infect. Viral Physiological Processes,Viral Physiology,Virus Physiological Processes,Physiology, Viral,Viral Physiological Concepts,Viral Physiological Phenomena,Viral Physiological Process,Virus Physiological Concepts,Virus Physiological Phenomenon,Virus Physiological Process,Virus Physiology,Concept, Viral Physiological,Concept, Virus Physiological,Concepts, Viral Physiological,Concepts, Virus Physiological,Phenomena, Viral Physiological,Phenomena, Virus Physiological,Phenomenon, Virus Physiological,Phenomenons, Virus Physiological,Physiological Process, Viral,Physiological Process, Virus,Physiological Processes, Viral,Physiological Processes, Virus,Physiology, Virus,Process, Viral Physiological,Process, Virus Physiological,Processes, Viral Physiological,Processes, Virus Physiological,Viral Physiological Concept,Virus Physiological Concept
D018894 Reverse Transcriptase Inhibitors Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. Reverse Transcriptase Inhibitor,Inhibitors, Reverse Transcriptase,Inhibitor, Reverse Transcriptase,Transcriptase Inhibitor, Reverse
D019943 Amino Acid Substitution The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties. Amino Acid Substitutions,Substitution, Amino Acid,Substitutions, Amino Acid

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