Mobility of the Yersinia High-Pathogenicity Island (HPI): transfer mechanisms of pathogenicity islands (PAIS) revisited (a review). 2007

Orsolya Benedek, and S Schubert
Department of Bacteriology, Max von Pettenkofer-Institute for Hygiene and Medical Microbiology, Ludwig-Maximilians-University, Munich, Germany.

Horizontal gene transfer (HGT) plays a key role in the evolution of bacterial pathogens. The exchange of genetic material supplies prokaryotes with several fitness traits enhancing their adaptive response to environmental changes. Pathogenicity islands (PAIs) represent an important and in most cases already immobilized subset of the different vehicles for HGT. Encoding several virulence factors PAls represent a major contribution to bacterial pathogenicity. Nonetheless, the transfer mechanisms of PAIs still remain elusive. We summarise the currently available data regarding the major ways of genetic mobilisation with a focus on the transfer of the Yersinia High-Pathogenicity Island (HPI).

UI MeSH Term Description Entries
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015007 Yersinia A genus of gram-negative, facultatively anaerobic rod- to coccobacillus-shaped bacteria that occurs in a broad spectrum of habitats.
D044404 Genomic Islands Distinct units in some bacterial, bacteriophage or plasmid GENOMES that are types of MOBILE GENETIC ELEMENTS. Encoded in them are a variety of fitness conferring genes, such as VIRULENCE FACTORS (in "pathogenicity islands or islets"), ANTIBIOTIC RESISTANCE genes, or genes required for SYMBIOSIS (in "symbiosis islands or islets"). They range in size from 10 - 500 kilobases, and their GC CONTENT and CODON usage differ from the rest of the genome. They typically contain an INTEGRASE gene, although in some cases this gene has been deleted resulting in "anchored genomic islands". Pathogenicity Islands,Anchored Genomic Islands,Genomic Islets,Pathogenicity Islets,Symbiosis Islands,Symbiosis Islets,Anchored Genomic Island,Genomic Island,Genomic Island, Anchored,Genomic Islands, Anchored,Genomic Islet,Island, Anchored Genomic,Island, Genomic,Island, Pathogenicity,Island, Symbiosis,Islands, Anchored Genomic,Islands, Genomic,Islands, Pathogenicity,Islands, Symbiosis,Islet, Genomic,Islet, Pathogenicity,Islet, Symbiosis,Islets, Genomic,Islets, Pathogenicity,Islets, Symbiosis,Pathogenicity Island,Pathogenicity Islet,Symbiosis Island,Symbiosis Islet
D022761 Gene Transfer, Horizontal The naturally occurring transmission of genetic information between organisms, related or unrelated, circumventing parent-to-offspring transmission. Horizontal gene transfer may occur via a variety of naturally occurring processes such as GENETIC CONJUGATION; GENETIC TRANSDUCTION; and TRANSFECTION. It may result in a change of the recipient organism's genetic composition (TRANSFORMATION, GENETIC). Gene Transfer, Lateral,Horizontal Gene Transfer,Lateral Gene Transfer,Recombination, Interspecies,Recombination, Interspecific,Gene Transfers, Lateral,Interspecies Recombination,Interspecific Recombination,Lateral Gene Transfers

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