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Assessment of radionuclidic impurities in 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) routine production. 2008
Mario Marengo, and
Filippo Lodi, and
Silvia Magi, and
Gianfranco Cicoria, and
Davide Pancaldi, and
Stefano Boschi
Medical Physics Department, S. Orsola-Malpighi Hospital, Bologna, Italy. marengo@med.unibo.it
In this paper, radionuclidic impurities generated during the bombardment of [18 O]water in the routine production of 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) were studied. In order to assess such impurities and the efficacy of purification methods through the different steps of the synthesis, samples of the target filters, purification columns, [18 O]water recovered after the synthesis, and the final solution was collected and their activities measured and analyzed by means of a gamma-ray spectrometry system. The data demonstrated that purification methods adopted for the synthesis provide the [18F]FDG radionuclidically pure, as requested by the EU Pharmacopeia.
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