Biomaterial Database

Dermatitis in a rhesus macaque (Macaca mulatta) experimentally infected with simian immunodeficiency virus. 2008

Jennifer Wilk, and Anne Lewis, and Victor Lukas

Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA. wilkj@ohsu.edu

Dermatopathies are common with human immunodeficiency virus (HIV) infection, affecting an estimated 90% of HIV patients. Opportunistic infections are common and include viral, bacterial and fungal etiologies. Dermal eruptions from highly active anti-retroviral therapy (HAART) or antibiotics such as trimethoprim-sulfamethoxazole (TMS) are also common, and can be challenging to differentiate from other causes of dermatitis. Presented is a challenging dermatology case involving a six year old male rhesus macaque experimentally infected with simian immunodeficiency virus (SIV). Skin cultures identified multi-antibiotic resistant Staphylococcus aureus, with incomplete resolution following appropriate antibiotic treatment. Skin biopsy results indicated non-specific dermatitis not consistent with typical SIV dermatitis and with a hypersensitivity component. Fungal culture revealed aspergillosis, and the patient responded favorably to oral itraconazole therapy.

UI	MeSH Term	Description	Entries
D008253	Macaca mulatta	A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.	Chinese Rhesus Macaques,Macaca mulatta lasiota,Monkey, Rhesus,Rhesus Monkey,Rhesus Macaque,Chinese Rhesus Macaque,Macaca mulatta lasiotas,Macaque, Rhesus,Rhesus Macaque, Chinese,Rhesus Macaques,Rhesus Macaques, Chinese,Rhesus Monkeys
D008297	Male		Males
D009894	Opportunistic Infections	An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.	Infection, Opportunistic,Infections, Opportunistic,Opportunistic Infection
D003872	Dermatitis	Any inflammation of the skin.	Dermatitides
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001228	Aspergillosis	Infections with fungi of the genus ASPERGILLUS.	Aspergillus Infection,Aspergilloses,Aspergillus Infections,Infection, Aspergillus,Infections, Aspergillus
D013203	Staphylococcal Infections	Infections with bacteria of the genus STAPHYLOCOCCUS.	Infections, Staphylococcal,Staphylococcus aureus Infection,Staphylococcal Infection,Staphylococcus aureus Infections
D015302	Simian Immunodeficiency Virus	Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.	SIV (Simian immunodeficiency virus),Immunodeficiency Viruses, Simian,Simian Immunodeficiency Viruses,Immunodeficiency Virus, Simian
D016097	Simian Acquired Immunodeficiency Syndrome	Acquired defect of cellular immunity that occurs naturally in macaques infected with SRV serotypes, experimentally in monkeys inoculated with SRV or MASON-PFIZER MONKEY VIRUS; (MPMV), or in monkeys infected with SIMIAN IMMUNODEFICIENCY VIRUS.	AIDS, Simian,SAIDS,Simian AIDS,Simian Acquired Immune Deficiency Syndrome,Simian Acquired Immuno-Deficiency Syndrome,AIDSs, Simian,Simian AIDSs,Simian Acquired Immuno Deficiency Syndrome