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Anti-BK virus activity of nucleoside analogs. 2008
Parmjeet Randhawa, and
Jiri Zemlicka, and
Andreas Sauerbrei, and
Chris Meier, and
Karl Y Hostetler, and
James R Beadle, and
Noush Afarin Farasati, and
Yuchen Huang, and
Matthews Bradley
Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room Medical Center, Pittsburgh, PA 15213, USA. randhawapa@upmc.edu
Polyomavirus BK is an important pathogen in transplant recipients with no effective therapy. This study demonstrates that alkoxyalkyl esters of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and fatty acid derivatives of 9-[2-(phosphonomethyoxy)ethyl]adenine (P393 and P405) are potent and selective inhibitors of BK virus replication in vitro, with a 50% effective concentration in the micromolar-to-nanomolar range.
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