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The capacity of monolayers of both normal human and xeroderma pigmentosum (XP) filbroblasts to support plaque formation by herpes simplex virus was decreased when the monolayers were ultraviolet (UV) irradiated and infected with virus. Fibroblasts of XP complementation groups A, B, and D were sensitive to UV, being 4-6 fold more sensitive than either fibroblasts of XP complementation group C or fibroblasts from a normal individual. When the monolayers were irradiated 4 days prior to infection, the capacity of normal fibroblasts to support herpes virus growth recovered, whereas the capacity of the XP strains decreased further compared to that measured when infection immediately followed irradiation. Concurrent experiments with UV-irradiated herpes virus showed that the survival of this virus did not increase when infection by irradiated virus immediately followed irradiation of the monolayers. However, if the monolayers were irradiated 4 days prior to infection, the survival of this virus increased by a factor of nearly 2. Such Weigle reactivation (WR) occurred at lower fluences to the XP fibroblasts than to normal fibroblasts, suggesting that WR results from residual cellular DNA damage left after excision repair.
C D Lytle, and
R S Day, and
K B Hellman, and
L E Bockstahler
June 1978,
Mutation research,
C D Lytle, and
R S Day, and
K B Hellman, and
L E Bockstahler
July 1986,
Mutation research,
C D Lytle, and
R S Day, and
K B Hellman, and
L E Bockstahler
January 1973,
Intervirology,
C D Lytle, and
R S Day, and
K B Hellman, and
L E Bockstahler
November 1984,
Molecular and cellular biology,
C D Lytle, and
R S Day, and
K B Hellman, and
L E Bockstahler
October 1970,
Nature,
C D Lytle, and
R S Day, and
K B Hellman, and
L E Bockstahler
April 1976,
Dermatologische Monatschrift,
C D Lytle, and
R S Day, and
K B Hellman, and
L E Bockstahler
June 1983,
Radiation research,
C D Lytle, and
R S Day, and
K B Hellman, and
L E Bockstahler
January 1974,
Photochemistry and photobiology,
C D Lytle, and
R S Day, and
K B Hellman, and
L E Bockstahler
November 1980,
Cancer research,
C D Lytle, and
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L E Bockstahler
May 1994,
Mutation research,
