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Structure of the hydrated platinum(II) ion and the cis-diammineplatinum(II) complex in acidic aqueous solution: an EXAFS study. 2008

Farideh Jalilehvand, and Luke J Laffin
Department of Chemistry, University of Calgary, Calgary, Alberta, Canada. faridehj@ucalgary.ca

Careful analysis of Pt L3-edge extended X-ray absorption fine structure (EXAFS) spectra shows that the hydrated platinum(II) ion in acidic (HClO 4) aqueous solution binds four water molecules with the Pt-O bond distance 2.01(2) A and one (or two) in the axial position at 2.39(2) A. The weak axial water coordination is in accordance with the unexpectedly small activation volume previously reported for water exchange in an interchange mechanism with associative character. The hydrated cis-diammineplatinum(II) complex has a similar coordination environment with two ammine and two aqua ligands strongly bound with Pt-O/N bond distances of 2.01(2) A and, in addition, one (or two) axial water molecule at 2.37(2) A. This result provides a new basis for theoretical computational studies aiming to connect the function of the anticancer drug cis-platin to its ligand exchange reactions, where usually four-coordinated square planar platinum(II) species are considered as the reactant and product. (195)Pt NMR spectroscopy has been used to characterize the Pt(II) complexes.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D010984 Platinum A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae". Platinum Black
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D003461 Crystallography The branch of science that deals with the geometric description of crystals and their internal arrangement. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Crystallographies
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D012996 Solutions The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed) Solution
D013052 Spectrometry, X-Ray Emission The spectrometric analysis of fluorescent X-RAYS, i.e. X-rays emitted after bombarding matter with high energy particles such as PROTONS; ELECTRONS; or higher energy X-rays. Identification of ELEMENTS by this technique is based on the specific type of X-rays that are emitted which are characteristic of the specific elements in the material being analyzed. The characteristic X-rays are distinguished and/or quantified by either wavelength dispersive or energy dispersive methods. Particle-Induced X-Ray Emission Spectrometry,Proton-Induced X-Ray Emission Spectrometry,Spectrometry, Particle-Induced X-Ray Emission,Spectrometry, Proton-Induced X-Ray Emission,Spectrometry, X-Ray Fluorescence,X-Ray Emission Spectrometry,X-Ray Emission Spectroscopy,X-Ray Fluorescence Spectrometry,Energy Dispersive X-Ray Fluorescence Spectrometry,Energy Dispersive X-Ray Fluorescence Spectroscopy,Energy Dispersive X-Ray Spectrometry,Energy Dispersive X-Ray Spectroscopy,Particle Induced X Ray Emission Spectrometry,Proton Induced X Ray Emission Spectrometry,Spectrometry, Particle Induced X Ray Emission,Spectrometry, Proton Induced X Ray Emission,Spectrometry, Xray Emission,Wavelength Dispersive X-Ray Fluorescence Spectrometry,Wavelength Dispersive X-Ray Fluorescence Spectroscopy,Wavelength Dispersive X-Ray Spectrometry,Wavelength Dispersive X-Ray Spectroscopy,X-Ray Fluorescence Spectroscopy,Xray Emission Spectroscopy,Emission Spectrometry, X-Ray,Emission Spectrometry, Xray,Emission Spectroscopy, X-Ray,Emission Spectroscopy, Xray,Energy Dispersive X Ray Fluorescence Spectrometry,Energy Dispersive X Ray Fluorescence Spectroscopy,Energy Dispersive X Ray Spectrometry,Energy Dispersive X Ray Spectroscopy,Fluorescence Spectrometry, X-Ray,Fluorescence Spectroscopy, X-Ray,Spectrometry, X Ray Emission,Spectrometry, X Ray Fluorescence,Spectroscopy, X-Ray Emission,Spectroscopy, X-Ray Fluorescence,Spectroscopy, Xray Emission,Wavelength Dispersive X Ray Fluorescence Spectrometry,Wavelength Dispersive X Ray Fluorescence Spectroscopy,Wavelength Dispersive X Ray Spectrometry,Wavelength Dispersive X Ray Spectroscopy,X Ray Emission Spectrometry,X Ray Emission Spectroscopy,X Ray Fluorescence Spectrometry,X Ray Fluorescence Spectroscopy,X-Ray Fluorescence Spectroscopies,Xray Emission Spectrometry

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