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Gnotobiotic newborn calves were found to be susceptible to infection with the reovirus-like agent of human infantile gastroenteritis (HRVL). Infection was based on (i) seroresponse using immunofluorescence and (ii) fecal shedding of virus particles using electron microscopy. Virus was detected in fecal samples for at least 2 to as long as 7 days after inoculation, although peak virus concentrations were observed on days 1 to 4. Diarrheal illness was observed in seven calves on second to fourth serial passage of HRVL in calves but in none of four animals studied on first passage. Diarrhea began 15 to 30.5 h (mean = 22.3 h) post-inoculation and lasted less than 24 h; three of the seven animals that developed diarrhea were also depressed or anorectic.
C A Mebus, and
R G Wyatt, and
R L Sharpee, and
M M Sereno, and
A R Kalica, and
A Z Kapikian, and
M J Twiehaus
January 1976,
Archives of virology,
C A Mebus, and
R G Wyatt, and
R L Sharpee, and
M M Sereno, and
A R Kalica, and
A Z Kapikian, and
M J Twiehaus
November 1975,
Lancet (London, England),
C A Mebus, and
R G Wyatt, and
R L Sharpee, and
M M Sereno, and
A R Kalica, and
A Z Kapikian, and
M J Twiehaus
August 1977,
Lancet (London, England),
C A Mebus, and
R G Wyatt, and
R L Sharpee, and
M M Sereno, and
A R Kalica, and
A Z Kapikian, and
M J Twiehaus
February 1977,
Journal of clinical microbiology,
C A Mebus, and
R G Wyatt, and
R L Sharpee, and
M M Sereno, and
A R Kalica, and
A Z Kapikian, and
M J Twiehaus
September 1976,
Lancet (London, England),
C A Mebus, and
R G Wyatt, and
R L Sharpee, and
M M Sereno, and
A R Kalica, and
A Z Kapikian, and
M J Twiehaus
November 1977,
Journal of clinical microbiology,
C A Mebus, and
R G Wyatt, and
R L Sharpee, and
M M Sereno, and
A R Kalica, and
A Z Kapikian, and
M J Twiehaus
April 1975,
Lancet (London, England),
C A Mebus, and
R G Wyatt, and
R L Sharpee, and
M M Sereno, and
A R Kalica, and
A Z Kapikian, and
M J Twiehaus
February 1978,
American journal of epidemiology,
C A Mebus, and
R G Wyatt, and
R L Sharpee, and
M M Sereno, and
A R Kalica, and
A Z Kapikian, and
M J Twiehaus
January 1976,
Lancet (London, England),
C A Mebus, and
R G Wyatt, and
R L Sharpee, and
M M Sereno, and
A R Kalica, and
A Z Kapikian, and
M J Twiehaus
August 1977,
JAMA,
