BIOMAT Database Logo BIOMAT Database Logo

Phytoecdysteroids increase protein synthesis in skeletal muscle cells. 2008

Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Biotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901, USA. jongf@eden.rutgers.edu

Phytoecdysteroids, which are structurally similar or identical to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. To study the mechanism of action of phytoecdysteroids in mammalian tissue, an in vitro cellular assay of protein synthesis was developed. In C2C12 murine myotubes and human primary myotubes, phytoecdysteroids increased protein synthesis by up to 20%. In vivo, ecdysteroids increased rat grip strength. Ecdysteroid-containing plant extracts produced similar results. The effect was inhibited by a phosphoinositide kinase-3 inhibitor, which suggests a PI3K-mediated mechanism.

UI MeSH Term Description Entries
D008297 Male Males
D010944 Plants Multicellular, eukaryotic life forms of kingdom Plantae. Plants acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations. It is a non-taxonomical term most often referring to LAND PLANTS. In broad sense it includes RHODOPHYTA and GLAUCOPHYTA along with VIRIDIPLANTAE. Plant
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D004441 Ecdysterone A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE. 20-Hydroxyecdysone,Beta-Ecdysone,Crustecdysone,20 Hydroxyecdysone,Beta Ecdysone
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014176 Protein Biosynthesis The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS. Genetic Translation,Peptide Biosynthesis, Ribosomal,Protein Translation,Translation, Genetic,Protein Biosynthesis, Ribosomal,Protein Synthesis, Ribosomal,Ribosomal Peptide Biosynthesis,mRNA Translation,Biosynthesis, Protein,Biosynthesis, Ribosomal Peptide,Biosynthesis, Ribosomal Protein,Genetic Translations,Ribosomal Protein Biosynthesis,Ribosomal Protein Synthesis,Synthesis, Ribosomal Protein,Translation, Protein,Translation, mRNA,mRNA Translations
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis.
April 2009, The Journal of physiology,
Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Branched-chain ketoacid ingestion: an alternative to efficiently increase skeletal muscle protein synthesis.
October 2019, The American journal of clinical nutrition,
Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Skeletal muscle atrophy, a link between depression of protein synthesis and increase in degradation.
March 2007, The Journal of biological chemistry,
Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Alcohol impairs protein synthesis and degradation in cultured skeletal muscle cells.
September 2001, Alcoholism, clinical and experimental research,
Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Protein synthesis in skeletal muscle: a comment.
January 1979, Muscle & nerve,
Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Phytoecdysteroids Do Not Have Anabolic Effects in Skeletal Muscle in Sedentary Aging Mice.
January 2021, International journal of environmental research and public health,
Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.
September 2014, The Journal of biological chemistry,
Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Insulin stimulation of protein synthesis in cultured skeletal and cardiac muscle cells.
July 1982, The American journal of physiology,
Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Endotoxemia reduces skeletal muscle protein synthesis in neonates.
November 2002, American journal of physiology. Endocrinology and metabolism,
Jonathan Gorelick-Feldman, and David Maclean, and Nebojsa Ilic, and Alexander Poulev, and Mary Ann Lila, and Diana Cheng, and Ilya Raskin
Protein synthesis by isolated skeletal muscle myofibrils.
June 1974, Indian journal of biochemistry & biophysics,
Copied contents to your clipboard!