-transparent.png){kind=logo}
Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. 2014
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
From the Baylor College of Medicine, Houston, Texas 77030.
Rapamycin at high doses (2-10 mg/kg body weight) inhibits mammalian target of rapamycin complex 1 (mTORC1) and protein synthesis in mice. In contrast, low doses of rapamycin (10 μg/kg) increase mTORC1 activity and protein synthesis in skeletal muscle. Similar changes are found with SLF (synthetic ligand for FKBP12, which does not inhibit mTORC1) and in mice with a skeletal muscle-specific FKBP12 deficiency. These interventions also increase Ca(2+) influx to enhance refilling of sarcoplasmic reticulum Ca(2+) stores, slow muscle fatigue, and increase running endurance without negatively impacting cardiac function. FKBP12 deficiency or longer treatments with low dose rapamycin or SLF increase the percentage of type I fibers, further adding to fatigue resistance. We demonstrate that FKBP12 and its ligands impact multiple aspects of muscle function.
Related Publications
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
March 2001,
Acta physiologica Scandinavica,
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
May 2008,
Journal of agricultural and food chemistry,
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
December 2010,
The Journal of biological chemistry,
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
September 2017,
Nature communications,
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
July 2006,
Diabetes,
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
July 2014,
The Journal of biological chemistry,
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
October 2019,
The American journal of clinical nutrition,
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
November 2003,
Bioorganic & medicinal chemistry letters,
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
June 2021,
eLife,
Chang Seok Lee, and
Dimitra K Georgiou, and
Adan Dagnino-Acosta, and
Jianjun Xu, and
Iskander I Ismailov, and
Mark Knoblauch, and
Tanner O Monroe, and
RuiRui Ji, and
Amy D Hanna, and
Aditya D Joshi, and
Cheng Long, and
Joshua Oakes, and
Ted Tran, and
Benjamin T Corona, and
Sabina Lorca, and
Christopher P Ingalls, and
Vihang A Narkar, and
Johanna T Lanner, and
J Henri Bayle, and
William J Durham, and
Susan L Hamilton
April 2001,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
