A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel. 2008

Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.

In this article, a novel local hydrophobic drug delivery system: nanoparticles in thermo-sensitive hydrogel, was demonstrated. First, honokiol, as a model hydrophobic drug, loaded poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCEC) nanoparticles were prepared by emulsion solvent evaporation method, and then were incorporated into thermo-sensitive F127 hydrous matrix. The obtained injectable hydrophobic drug delivery system can act as a depot for sustained release of honokiol in situ. The lower critical solution temperature (LCST) of the composite matrix increases with increase in the mass of incorporated nanoparticles, or with decrease in the amount of residual organic solvent in the system. Honokiol release profile in vitro was studied, and the results showed that honokiol could be sustained released from the system. The described injectable drug delivery system might have great potential application for local delivery of hydrophobic drugs such as honokiol.

UI MeSH Term Description Entries
D007279 Injections, Subcutaneous Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin. Subcutaneous Injections,Injection, Subcutaneous,Subcutaneous Injection
D011091 Polyesters Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours. Polyester
D011092 Polyethylene Glycols Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS. Macrogols,Polyoxyethylenes,Carbowax,Macrogol,Polyethylene Glycol,Polyethylene Oxide,Polyethyleneoxide,Polyglycol,Glycol, Polyethylene,Glycols, Polyethylene,Oxide, Polyethylene,Oxides, Polyethylene,Polyethylene Oxides,Polyethyleneoxides,Polyglycols,Polyoxyethylene
D003692 Delayed-Action Preparations Dosage forms of a drug that act over a period of time by controlled-release processes or technology. Controlled Release Formulation,Controlled-Release Formulation,Controlled-Release Preparation,Delayed-Action Preparation,Depot Preparation,Depot Preparations,Extended Release Formulation,Extended Release Preparation,Prolonged-Action Preparation,Prolonged-Action Preparations,Sustained Release Formulation,Sustained-Release Preparation,Sustained-Release Preparations,Timed-Release Preparation,Timed-Release Preparations,Controlled-Release Formulations,Controlled-Release Preparations,Extended Release Formulations,Extended Release Preparations,Slow Release Formulation,Sustained Release Formulations,Controlled Release Formulations,Controlled Release Preparation,Controlled Release Preparations,Delayed Action Preparation,Delayed Action Preparations,Formulation, Controlled Release,Formulations, Controlled Release,Prolonged Action Preparation,Release Formulation, Controlled,Release Formulations, Controlled,Sustained Release Preparation,Timed Release Preparation,Timed Release Preparations
D004655 Emulsions Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES. Emulsion
D005079 Excipients Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc. Excipient,Stabilizing Agent,Stabilizing Agents,Suspending Agent,Suspending Agents,Agent, Stabilizing,Agent, Suspending,Agents, Stabilizing,Agents, Suspending
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001713 Biphenyl Compounds Whitish aromatic crystalline organic compounds made up of two conjoined BENZENE rings. Compounds, Biphenyl
D012997 Solvents Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed) Solvent
D013696 Temperature The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms. Temperatures

Related Publications

Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
December 2011, Growth factors (Chur, Switzerland),
Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
April 2021, Colloids and surfaces. B, Biointerfaces,
Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
January 2018, Drug development and industrial pharmacy,
Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
August 2010, Macromolecular bioscience,
Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
November 2020, Journal of biomedical materials research. Part B, Applied biomaterials,
Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
March 2024, Advanced science (Weinheim, Baden-Wurttemberg, Germany),
Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
June 2022, Gels (Basel, Switzerland),
Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
October 1998, Journal of colloid and interface science,
Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
December 2019, ACS applied bio materials,
Maling Gou, and Xingyi Li, and Mei Dai, and Changyang Gong, and Xianhuo Wang, and Yao Xie, and Hongxin Deng, and Lijuan Chen, and Xia Zhao, and Zhiyong Qian, and Yuquan Wei
January 2015, Nanotechnology,
Copied contents to your clipboard!