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The present series of studies were performed to test the hypothesis that ethanol in the blood may play a role in the pathogenesis of gastric mucosal injury. Another hypothesis to be examined was that endothelin may be involved in ethanol-induced gastric mucosal injury. Elevated levels of blood ethanol induced by intraperitoneal infusion of ethanol increased vulnerability of the stomach to hydrochloric acid in a dose-dependent manner in rats. This may be due to impaired gastric mucosal hemodynamics and oxygenation as demonstrated by the results obtained by organ reflectance spectrophotometry (decreases in indices of mucosal hemoglobin contents and hemoglobin oxygen saturation). Ethanol infusion caused a dose-dependent increase in gastric vascular resistance in perfused rabbit stomach, which was accompanied by an increased production of endothelin-1. The results suggest that endothelin may be involved in the pathogenesis of ethanol-induced gastric mucosal injury.
E Masuda, and
S Kawano, and
K Nagano, and
T Ogihara, and
S Tsuji, and
H Tanimura, and
Y Ishigami, and
M Tsujii, and
N Hayashi, and
Y Sasayama
January 1985,
Gastroenterologie clinique et biologique,
E Masuda, and
S Kawano, and
K Nagano, and
T Ogihara, and
S Tsuji, and
H Tanimura, and
Y Ishigami, and
M Tsujii, and
N Hayashi, and
Y Sasayama
January 1986,
Pharmacology,
E Masuda, and
S Kawano, and
K Nagano, and
T Ogihara, and
S Tsuji, and
H Tanimura, and
Y Ishigami, and
M Tsujii, and
N Hayashi, and
Y Sasayama
January 1998,
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract,
E Masuda, and
S Kawano, and
K Nagano, and
T Ogihara, and
S Tsuji, and
H Tanimura, and
Y Ishigami, and
M Tsujii, and
N Hayashi, and
Y Sasayama
March 2000,
Journal of gastroenterology and hepatology,
E Masuda, and
S Kawano, and
K Nagano, and
T Ogihara, and
S Tsuji, and
H Tanimura, and
Y Ishigami, and
M Tsujii, and
N Hayashi, and
Y Sasayama
October 1989,
Gastroenterologia Japonica,
E Masuda, and
S Kawano, and
K Nagano, and
T Ogihara, and
S Tsuji, and
H Tanimura, and
Y Ishigami, and
M Tsujii, and
N Hayashi, and
Y Sasayama
May 1997,
The Tokai journal of experimental and clinical medicine,
E Masuda, and
S Kawano, and
K Nagano, and
T Ogihara, and
S Tsuji, and
H Tanimura, and
Y Ishigami, and
M Tsujii, and
N Hayashi, and
Y Sasayama
January 1993,
Journal of gastroenterology and hepatology,
E Masuda, and
S Kawano, and
K Nagano, and
T Ogihara, and
S Tsuji, and
H Tanimura, and
Y Ishigami, and
M Tsujii, and
N Hayashi, and
Y Sasayama
October 1990,
Prostaglandins,
E Masuda, and
S Kawano, and
K Nagano, and
T Ogihara, and
S Tsuji, and
H Tanimura, and
Y Ishigami, and
M Tsujii, and
N Hayashi, and
Y Sasayama
December 2008,
Canadian journal of physiology and pharmacology,
E Masuda, and
S Kawano, and
K Nagano, and
T Ogihara, and
S Tsuji, and
H Tanimura, and
Y Ishigami, and
M Tsujii, and
N Hayashi, and
Y Sasayama
March 1991,
Alcoholism, clinical and experimental research,
