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Sixty-five patients with operable breast cancer were studied to assess the reliability of immunocytochemical analysis of oestrogen receptor (ER-ICA) in specimens obtained by percutaneous fine needle aspiration. Results obtained with the commercially available ER-ICA kit were compared with those obtained by the routine biochemical radioligand assay of oestrogen receptor (ER) on excised tumour specimens. Fifty-two of 65 percutaneous aspirates were evaluable. Of these, thirty-five (67%) were ER positive by the radioligand method. ER-ICA was found to be a reliable method for oestrogen receptor assay, with a high concordance (90.4%) between it and the radioligand essay. The ER-ICA assay had a sensitivity of 89%, specificity of 94%, positive predictive value of 97% and negative predictive value of 80%. ER-ICA assay performed on material obtained by fine-needle aspiration is a reliable method of ER assay. It can replace formal biopsy for patients with inoperable primary tumours or accessible metastases.
P R Kitchen, and
R G Stillwell, and
M A Henderson, and
R C Bennett, and
G C Rennie, and
S J Kou, and
T Georgiou, and
H Ayberk
February 2013,
Cytopathology : official journal of the British Society for Clinical Cytology,
P R Kitchen, and
R G Stillwell, and
M A Henderson, and
R C Bennett, and
G C Rennie, and
S J Kou, and
T Georgiou, and
H Ayberk
January 1989,
British journal of cancer,
P R Kitchen, and
R G Stillwell, and
M A Henderson, and
R C Bennett, and
G C Rennie, and
S J Kou, and
T Georgiou, and
H Ayberk
January 1985,
Acta cytologica,
P R Kitchen, and
R G Stillwell, and
M A Henderson, and
R C Bennett, and
G C Rennie, and
S J Kou, and
T Georgiou, and
H Ayberk
October 1987,
American journal of clinical pathology,
P R Kitchen, and
R G Stillwell, and
M A Henderson, and
R C Bennett, and
G C Rennie, and
S J Kou, and
T Georgiou, and
H Ayberk
September 1987,
Lancet (London, England),
P R Kitchen, and
R G Stillwell, and
M A Henderson, and
R C Bennett, and
G C Rennie, and
S J Kou, and
T Georgiou, and
H Ayberk
December 1985,
The British journal of surgery,
P R Kitchen, and
R G Stillwell, and
M A Henderson, and
R C Bennett, and
G C Rennie, and
S J Kou, and
T Georgiou, and
H Ayberk
April 1987,
European journal of cancer & clinical oncology,
P R Kitchen, and
R G Stillwell, and
M A Henderson, and
R C Bennett, and
G C Rennie, and
S J Kou, and
T Georgiou, and
H Ayberk
January 1990,
Acta cytologica,
P R Kitchen, and
R G Stillwell, and
M A Henderson, and
R C Bennett, and
G C Rennie, and
S J Kou, and
T Georgiou, and
H Ayberk
January 1990,
Acta cytologica,
P R Kitchen, and
R G Stillwell, and
M A Henderson, and
R C Bennett, and
G C Rennie, and
S J Kou, and
T Georgiou, and
H Ayberk
August 1994,
Analytical and quantitative cytology and histology,
