This paper examines the findings and implications of the cross-linguistic acquisition of #sC clusters in relation to sonority patterns. Data from individual studies on English, Dutch, Norwegian, and Hebrew are compared for accuracy of production as well as the reductions with respect to potential differences across subtypes of #sC groups. In all four languages, a great deal of variability occurred both within and across children, but a number of general patterns were noted. While all four languages showed similar behaviour in reduction patterns, clear differences between the three Germanic languages-English, Dutch, and Norwegian-and Hebrew were found in the accuracy rate of #sC clusters that have a larger sonority distance between C1 and C2, in a binary split of /s/+[+cont.] versus /s/+[-cont.], and in #sC clusters versus non-/s/-clusters. Patterns in cluster reductions were, in general, supportive of the factorial typology of Pater and Barlow, while pointing at some difficulties for the predictions of the headedness approach advanced by Goad and Rose, and Jongstra. This cross-linguistic description of patterns of s-clusters increases our knowledge of typical phonological development and helps selecting targets in clinical context.