-transparent.png){kind=logo}
Human fibroblasts have the capacity to release superoxide radicals upon stimulation of an electron transport system similar to the NADPH oxidase of leukocytes. Two components of the NADPH oxidase system, (1) a flavoprotein of 45 kDa which binds diphenylene iodonium (a compound described as a specific inhibitor of the leukocyte NADPH oxidase), and (2) a low-potential cytochrome b, are present in fibroblast membranes. Fibroblasts exhibit these compounds at lower concentrations than do polymorphonuclear leukocytes or B-lymphocytes. The superoxide-generating system is rather uniformly associated with the outer cell membrane, as shown by light and electron microscopy. Superoxide release upon stimulation with various agents was prevented by the addition of micromolar concentrations of diphenylene iodonium, making an NADPH oxidase a likely source.
B Meier, and
A R Cross, and
J T Hancock, and
F J Kaup, and
O T Jones
June 1995,
The American journal of physiology,
B Meier, and
A R Cross, and
J T Hancock, and
F J Kaup, and
O T Jones
April 1986,
The Journal of biological chemistry,
B Meier, and
A R Cross, and
J T Hancock, and
F J Kaup, and
O T Jones
October 2004,
The Journal of biological chemistry,
B Meier, and
A R Cross, and
J T Hancock, and
F J Kaup, and
O T Jones
March 1992,
Biochemical pharmacology,
B Meier, and
A R Cross, and
J T Hancock, and
F J Kaup, and
O T Jones
March 1987,
The Journal of biological chemistry,
B Meier, and
A R Cross, and
J T Hancock, and
F J Kaup, and
O T Jones
December 1988,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
B Meier, and
A R Cross, and
J T Hancock, and
F J Kaup, and
O T Jones
February 2000,
Biochemical and biophysical research communications,
B Meier, and
A R Cross, and
J T Hancock, and
F J Kaup, and
O T Jones
January 2012,
Journal of clinical biochemistry and nutrition,
B Meier, and
A R Cross, and
J T Hancock, and
F J Kaup, and
O T Jones
February 1994,
Biotechnology and applied biochemistry,
B Meier, and
A R Cross, and
J T Hancock, and
F J Kaup, and
O T Jones
September 2002,
Cellular and molecular life sciences : CMLS,
