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The case of a 40-year-old woman with primary small cell carcinoma of the cervix is reported. She developed widespread metastates and florid Cushing's syndrome. Serum ACTH levels were greatly elevated and no site of production other than the tumor could be demonstrated at autopsy. The tumor cells demonstrated features characteristic of cells of the APUD series. Such cells have been demonstrated in normal cervical epithelium; it is likely that they may become malignant, giving rise to tumors with a potential to secrete polypeptide hormones. This case suggests that endocrine active "Apudomas" may arise from the uterine cervix. Certainly, patients with small cell carcinoma of the cervix should be investigated with appropriate serum assays for polypeptide hormones.
H W Jones, and
S Plymate, and
F B Gluck, and
P A Miles, and
J F Greene
January 2024,
Frontiers in oncology,
H W Jones, and
S Plymate, and
F B Gluck, and
P A Miles, and
J F Greene
August 1997,
Zhonghua fu chan ke za zhi,
H W Jones, and
S Plymate, and
F B Gluck, and
P A Miles, and
J F Greene
May 1995,
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society,
H W Jones, and
S Plymate, and
F B Gluck, and
P A Miles, and
J F Greene
January 1996,
Clinical oncology (Royal College of Radiologists (Great Britain)),
H W Jones, and
S Plymate, and
F B Gluck, and
P A Miles, and
J F Greene
July 1981,
The New England journal of medicine,
H W Jones, and
S Plymate, and
F B Gluck, and
P A Miles, and
J F Greene
November 1979,
Cancer,
H W Jones, and
S Plymate, and
F B Gluck, and
P A Miles, and
J F Greene
November 1998,
Gynecologic oncology,
H W Jones, and
S Plymate, and
F B Gluck, and
P A Miles, and
J F Greene
October 1988,
Cancer,
H W Jones, and
S Plymate, and
F B Gluck, and
P A Miles, and
J F Greene
January 2007,
Acta cytologica,
H W Jones, and
S Plymate, and
F B Gluck, and
P A Miles, and
J F Greene
January 1998,
Gynecologic oncology,
