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The case of a 38-year-old female with primary argyrophil cell carcinoma of the uterine cervix is reported. Two years after operation the patient developed widespread metastases with typical Cushing's syndrome. Microscopically, the tumor consisted of solid anaplastic cells, adenocarcinoma, and squamous cells. The plasma levels of ACTH and cortisol were elevated. Many cells of both the primary and metastatic tumors showed argyrophilia. Almost all the cells of the metastases contained numerous round secretory granules measuring about 117 micrometers in diameter. Small rod-shaped or larger round secretory granules, measuring 250 and 430 micrometers respectively, were also found in a few of these cells. The tumors in the right lung, pancreas, and kidney contained high levels of ACTH, beta-MSH, serotonin, histamine, and amylase. This is the first report of ectopic production of these five substances from argyrophil cell carcinoma of the uterine cervix.
M Matsuyama, and
T Inoue, and
Y Ariyoshi, and
M Doi, and
T Suchi, and
T Sato, and
K Tashiro, and
T Chihara
January 1976,
Cancer,
M Matsuyama, and
T Inoue, and
Y Ariyoshi, and
M Doi, and
T Suchi, and
T Sato, and
K Tashiro, and
T Chihara
December 1969,
Archives of internal medicine,
M Matsuyama, and
T Inoue, and
Y Ariyoshi, and
M Doi, and
T Suchi, and
T Sato, and
K Tashiro, and
T Chihara
January 1984,
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists,
M Matsuyama, and
T Inoue, and
Y Ariyoshi, and
M Doi, and
T Suchi, and
T Sato, and
K Tashiro, and
T Chihara
February 1977,
The American journal of medicine,
M Matsuyama, and
T Inoue, and
Y Ariyoshi, and
M Doi, and
T Suchi, and
T Sato, and
K Tashiro, and
T Chihara
June 1976,
The Kobe journal of medical sciences,
M Matsuyama, and
T Inoue, and
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M Doi, and
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K Tashiro, and
T Chihara
December 1977,
Connecticut medicine,
M Matsuyama, and
T Inoue, and
Y Ariyoshi, and
M Doi, and
T Suchi, and
T Sato, and
K Tashiro, and
T Chihara
November 1998,
Gynecologic oncology,
M Matsuyama, and
T Inoue, and
Y Ariyoshi, and
M Doi, and
T Suchi, and
T Sato, and
K Tashiro, and
T Chihara
October 1976,
Cancer,
M Matsuyama, and
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M Doi, and
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T Sato, and
K Tashiro, and
T Chihara
August 1991,
Japanese journal of clinical oncology,
M Matsuyama, and
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Y Ariyoshi, and
M Doi, and
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T Sato, and
K Tashiro, and
T Chihara
December 1988,
Japanese journal of cancer research : Gann,
