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Nucleoside phosphonic acids in thymidine phosphorylase inhibition: structure-activity relationship. 2008
Natalya Panova, and
Ivana Kosiová, and
Magdalena Petrová, and
Václav Vanĕk, and
Radek Liboska, and
Sona Kovacková, and
Petr Kocalka, and
Sárka Králíková, and
Zdenĕk Tocík, and
Ondrej Páv, and
Ondrej Paces, and
Dominik Rejman, and
Ivan Rosenberg
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
A number of structurally diverse nucleoside phosphonic acids have been tested against human recombinant thymidine phosphorylase and human platelets supernatant using 2'-deoxy-5-nitrouridine as the substrate. We have selected several inhibitors working at micromolar level as lead structures for further evaluation.
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